Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 15/20 | 0.45 |
| ▸ | BRAF | P15056 | 14/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5593311 | 0.77 | RAF1 (0.46) | RAF1BRAFCSF1R | |
| SCHEMBL4407767 | 0.76 | CNR1 (0.43) | RAF1BRAFCNR1NPC1USP2 | |
| SCHEMBL5593352 | 0.72 | RAF1 (0.41) | RAF1BRAFNPC1USP2ALDH1A1 | |
| SCHEMBL5593303 | 0.71 | RAF1 (0.59) | RAF1BRAFMAPK14 | |
| SCHEMBL4412693 | 0.71 | RAF1 (0.49) | RAF1BRAFCSF1R | |
| SCHEMBL4541481 | 0.71 | RAB9A (0.47) | RAF1BRAFNPC1RAB9AMAPK14 | |
| SCHEMBL5593445 | 0.70 | RAF1 (0.58) | RAF1BRAFMAPK14CSF1R | |
| SCHEMBL4412596 | 0.70 | ACKR3 (0.43) | RAF1BRAFNPC1RAB9AMAPK14 | |
| SCHEMBL4409551 | 0.70 | RAF1 (0.43) | RAF1BRAFCSF1R | |
| SCHEMBL4410942 | 0.70 | BRAF (0.45) | RAF1BRAFCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |