Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Triflupromazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 5/20 | 0.64 |
| ▸ | TP53 | P04637 | 7/20 | 0.85 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.85 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.85 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.85 |
| ▸ | HTR1A | P08908 | 6/20 | 0.85 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.85 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.85 |
| ▸ | DRD1 | P21728 | 5/20 | 0.85 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.85 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.85 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.85 |
| ▸ | DRD3 | P35462 | 5/20 | 0.85 |
| ▸ | THPO | P40225 | 5/20 | 0.85 |
| ▸ | MTOR | P42345 | 5/20 | 0.85 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.85 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.85 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.85 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.85 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triflupromazine SCHEMBL32668886 | 0.92 | CYP1A2 (1.00) | TP53CYP1A2CYP2D6MAPK1HTR1A | |
| Triflupromazine SCHEMBL44085 | 0.92 | CYP1A2 (1.00) | TP53CYP1A2CYP2D6MAPK1HTR1A | |
| Triflupromazine SCHEMBL29419087 | 0.91 | LMNA (1.00) | TP53CYP1A2CYP2D6MAPK1HTR1A | |
| Triflupromazine SCHEMBL30903901 | 0.91 | LMNA (1.00) | TP53CYP1A2CYP2D6MAPK1HTR1A | |
| Triflupromazine SCHEMBL317144 | 0.91 | LMNA (1.00) | TP53CYP1A2CYP2D6MAPK1HTR1A | |
| Triflupromazine SCHEMBL317145 | 0.90 | CYP1A2 (0.95) | TP53CYP1A2CYP2D6MAPK1HTR1A | |
| SCHEMBL7750160 | 0.88 | TP53 (0.91) | TP53CYP1A2CYP2D6MAPK1HTR1A | |
| SCHEMBL23353457 | 0.88 | TP53 (0.85) | TP53CYP1A2CYP2D6MAPK1HTR1A | |
| Trifluoperazine SCHEMBL28057424 | 0.87 | FPR2 (0.86) | TP53CYP1A2CYP2D6MAPK1HTR1A | |
| Triflupromazine SCHEMBL28057425 | 0.86 | CYP1A2 (0.87) | TP53CYP1A2CYP2D6MAPK1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996040084-A1 | COMPOSITIONS AND METHODS FOR USE OF PRESSURE SENSITIVE ADHESIVE TRANSDERMAL DEVICES CONTAINING A BIOADHESIVE HUMECTANT | NOVEN PHARMACEUTICALS, INC. (US) | 1996-12-19 | — | — | WO | disclosed |
| WO-1996040086-A2 | COMPOSITIONS AND METHODS FOR TOPICAL ADMINISTRATION OF PHARMACEUTICALLY ACTIVE AGENTS | NOVEN PHARMACEUTICALS, INC. (US) | 1996-12-19 | — | — | WO | disclosed |