Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JUN | P05412 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4414469 | 0.89 | JUN (0.33) | JUNMAPK10TNK2SYK | |
| SCHEMBL4420521 | 0.86 | TNK2 (0.36) | JUNMAPK10TNK2SYKLMNA | |
| SCHEMBL4423212 | 0.68 | CNR2 (0.39) | SYKRAB9ALMNA | |
| SCHEMBL4413379 | 0.68 | PTK2 (0.44) | — | |
| SCHEMBL4412949 | 0.67 | IKBKB (0.45) | SYKMAPT | |
| SCHEMBL4417185 | 0.67 | PTK2 (0.40) | MAPK10SYK | |
| SCHEMBL4424495 | 0.67 | MET (0.34) | — | |
| SCHEMBL4420608 | 0.67 | CDK4 (0.44) | — | |
| SCHEMBL4414503 | 0.67 | RIPK2 (0.49) | SYKSTK17A | |
| SCHEMBL4417053 | 0.67 | MAPK10 (0.38) | MAPK10SYKSTK17A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615921-B1 | PYRIDO 2,3-D PYRIMIDIN-7-CARBOXYLIC ACID DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | HOFFMANN LA ROCHE (CH) | 2009-03-18 | — | — | EP | claimed |
| EP-1615921-B1 | PYRIDO 2,3-D PYRIMIDIN-7-CARBOXYLIC ACID DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | HOFFMANN LA ROCHE (CH) | 2009-03-18 | — | — | EP | disclosed |