Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 5/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 4/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.43 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 3/20 | 0.42 |
| ▸ | EGFR | P00533 | 4/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | CCND2 | P30279 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4423212 | 0.82 | CNR2 (0.39) | AURKAEGFRJAK2 | |
| SCHEMBL4414469 | 0.79 | JUN (0.33) | — | |
| SCHEMBL4424495 | 0.79 | MET (0.34) | ALKEGFR | |
| SCHEMBL4410708 | 0.79 | MARK3 (0.44) | AURKAMAP3K7MAP2K1INSREGFR | |
| SCHEMBL4422225 | 0.78 | CDK4 (0.52) | CDK4AURKACCND1CDK1CDK2 | |
| SCHEMBL4412920 | 0.78 | MAPK10 (0.36) | CDK4CCND1CDK2EGFRCCND2 | |
| SCHEMBL4415084 | 0.78 | MAPK10 (0.36) | CDK4CCND1CDK2BRD4EGFR | |
| SCHEMBL4416334 | 0.77 | IKBKB (0.42) | CDK4CDK1CDK2 | |
| SCHEMBL4413312 | 0.77 | LMNA (0.42) | AURKAEGFR | |
| SCHEMBL4411774 | 0.77 | MAPK10 (0.36) | CDK4AURKACCND1CDK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615921-B1 | PYRIDO 2,3-D PYRIMIDIN-7-CARBOXYLIC ACID DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | HOFFMANN LA ROCHE (CH) | 2009-03-18 | — | — | EP | claimed |