Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JUN | P05412 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.31 |
| ▸ | ULK1 | O75385 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4411447 | 0.89 | JUN (0.34) | JUNMAPK10TNK2SYK | |
| SCHEMBL4423212 | 0.81 | CNR2 (0.39) | SYKPTK2TSHR | |
| SCHEMBL4420521 | 0.80 | TNK2 (0.36) | JUNMAPK10TNK2SYK | |
| SCHEMBL4420608 | 0.79 | CDK4 (0.44) | — | |
| SCHEMBL4424495 | 0.79 | MET (0.34) | — | |
| SCHEMBL4416334 | 0.75 | IKBKB (0.42) | SYK | |
| SCHEMBL4415084 | 0.74 | MAPK10 (0.36) | MAPK10PTK2ULK1 | |
| SCHEMBL4412920 | 0.74 | MAPK10 (0.36) | MAPK10PTK2ULK1 | |
| SCHEMBL4413502 | 0.73 | CDK1 (0.36) | SYKPTK2 | |
| SCHEMBL4413555 | 0.73 | BRAF (0.38) | MAPK10SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615921-B1 | PYRIDO 2,3-D PYRIMIDIN-7-CARBOXYLIC ACID DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | HOFFMANN LA ROCHE (CH) | 2009-03-18 | — | — | EP | claimed |