Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4428827 | 0.77 | EGFR (0.50) | KDRFLT3SYKMAPTRAB9A | |
| SCHEMBL4414311 | 0.76 | EGFR (0.53) | ALDH1A1KDRSYKMAPTKMT2A | |
| SCHEMBL4417948 | 0.75 | GAA (0.43) | RETKDRDAPK3PRKD3MAP4K4 | |
| SCHEMBL4427810 | 0.74 | EGFR (0.45) | CYP3A4SYKMAPTKMT2AMEN1 | |
| SCHEMBL4414428 | 0.74 | EGFR (0.47) | HIF1AHSD17B10HTTRAB9AEGFR | |
| SCHEMBL4413885 | 0.74 | FYN (0.46) | ALDH1A1HSD17B10RETKDRDAPK3 | |
| SCHEMBL1306611 | 0.73 | IRAK4 (0.45) | CDC7RETKDRDAPK3PRKD3 | |
| SCHEMBL30250674 | 0.72 | CDC7 (0.70) | CDC7ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4412315 | 0.71 | ABCG2 (0.44) | ALDH1A1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL4412618 | 0.71 | EGFR (0.49) | RETKDRMAP4K4CDK7DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601713-B2 | Kinase inhibitors and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2009-10-13 | — | — | US | claimed |