Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | ULK1 | O75385 | 2/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.42 |
| ▸ | CLK2 | P49760 | 2/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4417948 | 0.75 | GAA (0.43) | FYNDYRK1ACLK2CLK4DYRK1B | |
| SCHEMBL4428827 | 0.75 | EGFR (0.50) | FLT1KDRFLT3MAPTNPC1 | |
| SCHEMBL4427810 | 0.74 | EGFR (0.45) | KMT2AMAPTMEN1 | |
| SCHEMBL4414428 | 0.74 | EGFR (0.47) | ABL1SMN1; SMN2RAB9AHSD17B10 | |
| SCHEMBL4414311 | 0.74 | EGFR (0.53) | FLT1KDRPRKCQKMT2AMAPT | |
| SCHEMBL4411564 | 0.74 | CDC7 (0.49) | DYRK1ACLK2CLK4DAPK3PRKD3 | |
| SCHEMBL1307044 | 0.74 | DYRK1A (0.39) | FYNPRMT1DYRK1ACLK2CLK4 | |
| SCHEMBL4411964 | 0.73 | TTBK1 (0.49) | FYNDYRK1ACLK2CLK4CHEK1 | |
| SCHEMBL4414871 | 0.72 | MAPT (0.45) | JAK2MAP4K4ABL1NTRK1PIM1 | |
| SCHEMBL14868822 | 0.71 | FYN (0.64) | FYNULK1DYRK1ACLK2CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601713-B2 | Kinase inhibitors and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2009-10-13 | — | — | US | claimed |