Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | CSF1R | P07333 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | LTK | P29376 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4421897 | 0.89 | MAPK1 (0.39) | GAAGFERMAP2K1TDO2KDM4E | |
| SCHEMBL4414428 | 0.80 | EGFR (0.47) | GFERMAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL4410317 | 0.80 | TAAR1 (0.48) | KDRFLT3DAPK3PRKD3PIM1 | |
| SCHEMBL4414311 | 0.80 | EGFR (0.53) | KDRFLT1PRKCQMAPTRAB9A | |
| SCHEMBL4428827 | 0.76 | EGFR (0.50) | KDRFLT3FLT1MAPTRAB9A | |
| SCHEMBL4427810 | 0.75 | EGFR (0.45) | GFERMAPTMEN1KMT2APIK3CA | |
| SCHEMBL4412618 | 0.75 | EGFR (0.49) | KDRMAP4K4RETLTKGRK5 | |
| SCHEMBL4411564 | 0.75 | CDC7 (0.49) | GAAKDRFLT3DAPK3PRKD3 | |
| SCHEMBL4412315 | 0.75 | ABCG2 (0.44) | GRM4MAPTRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL4413885 | 0.75 | FYN (0.46) | GAAKDRCSF1RFLT3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601713-B2 | Kinase inhibitors and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2009-10-13 | — | — | US | claimed |