Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 5/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 4/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 2/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | TEK | Q02763 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4417430 | 0.85 | BRAF (0.41) | LCKBRAFEGFRMEN1KMT2A | |
| SCHEMBL4412618 | 0.78 | EGFR (0.49) | KDRAURKBEGFRSRCMEN1 | |
| SCHEMBL4416584 | 0.78 | MEN1 (0.41) | EGFRMEN1KMT2A | |
| SCHEMBL4411784 | 0.78 | MAPT (0.52) | EGFRKMT2ADHFR | |
| SCHEMBL14044911 | 0.77 | ADORA3 (0.47) | KDRAURKBLCKBRAFEGFR | |
| SCHEMBL4414428 | 0.73 | EGFR (0.47) | EGFRADORA2A | |
| SCHEMBL4417948 | 0.72 | GAA (0.43) | KDRLCKSRCMEN1KMT2A | |
| SCHEMBL4417806 | 0.71 | SYK (0.43) | EGFRMEN1KMT2A | |
| SCHEMBL4427810 | 0.71 | EGFR (0.45) | BRAFEGFRMEN1KMT2A | |
| SCHEMBL4412315 | 0.71 | ABCG2 (0.44) | EGFRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601713-B2 | Kinase inhibitors and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2009-10-13 | — | — | US | claimed |