Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 5/20 | 0.40 |
| ▸ | JAK3 | P52333 | 5/20 | 0.40 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | IKBKE | Q14164 | 5/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20976339 | 0.83 | LTA4H (0.44) | GAACYP11B1CYP11B2 | |
| SCHEMBL4422019 | 0.80 | MEN1 (0.54) | GAAMEN1KMT2AHSD17B10CYP11B1 | |
| SCHEMBL30037424 | 0.79 | L3MBTL1 (0.37) | GAAJAK1JAK3JAK2IKBKE | |
| SCHEMBL23988336 | 0.78 | TSHR (0.46) | GAAJAK1MEN1KMT2AHSD17B10 | |
| SCHEMBL3258043 | 0.77 | GAA (0.44) | GAAJAK1JAK3JAK2IKBKE | |
| SCHEMBL26606583 | 0.77 | JAK1 (0.38) | JAK1JAK3JAK2IKBKETBK1 | |
| SCHEMBL15134364 | 0.75 | JAK2 (0.36) | JAK1JAK3JAK2IKBKETBK1 | |
| SCHEMBL23773512 | 0.74 | SYK (0.40) | GAAJAK1JAK3JAK2IKBKE | |
| SCHEMBL29097052 | 0.74 | LMNA (0.42) | GAAJAK1JAK3JAK2IKBKE | |
| SCHEMBL24570289 | 0.73 | GABRA1 (0.44) | JAK1JAK3JAK2IKBKETBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |
| US-6953803-B1 | 1-[(N-(2-(diethylamino)ethyl)-N-(4-(4-trifluoromethylphenyl)benzyl)aminocarbonylmethyl)]-2-(4-fluorobenzyl)thio-5-(1-methyl-4-pyrazolylmethyl)pyrimidin-4-one; enzyme inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2); atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-10-11 | — | — | US | disclosed |