Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 7/20 | 0.46 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 5/20 | 0.46 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.46 |
| ▸ | GPR183 | P32249 | 1/20 | 0.46 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.46 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.43 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.43 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL7621218 | 1.00 | THRA (0.49) | THRATHRBS1PR1TNNC1S1PR4 | |
| Tromethamine SCHEMBL11416037 | 1.00 | THRA (0.49) | THRATHRBS1PR1TNNC1S1PR4 | |
| Tromethamine SCHEMBL7568694 | 0.95 | THRA (0.42) | THRATHRBS1PR1TNNC1S1PR4 | |
| SCHEMBL11674760 | 0.89 | THRA (0.58) | THRATHRBLIPGALOX5PTGS2 | |
| SCHEMBL4443988 | 0.89 | THRA (0.58) | THRATHRBLIPGALOX5PTGS2 | |
| SCHEMBL30887815 | 0.89 | THRA (0.58) | THRATHRBLIPGALOX5PTGS2 | |
| SCHEMBL4445684 | 0.89 | THRA (0.58) | THRATHRBLIPGALOX5PTGS2 | |
| SCHEMBL7196282 | 0.89 | THRA (0.58) | THRATHRBLIPGALOX5PTGS2 | |
| SCHEMBL247534 | 0.89 | THRA (0.58) | THRATHRBLIPGALOX5PTGS2 | |
| SCHEMBL30380227 | 0.89 | THRA (0.58) | THRATHRBLIPGALOX5PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3604 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122011916-A | Salt mist-resistant high-temperature-resistant friction-resistant coating as well as preparation method and application thereof | 株洲中车时代半导体股份有限公司 | 2026-05-12 | — | — | CN | claimed |
| CN-121574533-A | High-strength bio-based TPU film with controllable degradation characteristic and preparation method thereof | 浙江安布雷拉新材料制造有限公司 | 2026-02-27 | — | — | CN | claimed |
| CN-121574354-A | Copolyester for dental diaphragm, preparation method of copolyester, preparation method of polyester particles and processing method of polyester film or plate | 苏州亚科科技股份有限公司 | 2026-02-27 | — | — | CN | claimed |
| CN-116120631-B | Anti-aging agent composition, application thereof and anti-aging polymer material | 天津利安隆新材料股份有限公司 | 2025-06-13 | — | — | CN | claimed |
| CN-119735880-B | Polyethylene composite material and preparation method thereof | 兰州石化职业技术大学 | 2025-06-03 | — | — | CN | claimed |
| CN-120081989-A | Transparent high-impact heat-resistant MBS resin and preparation method thereof | 山东源邦新材料股份有限公司 | 2025-06-03 | — | — | CN | claimed |
| CN-120061018-A | Polyester industrial yarn activation oiling agent and preparation method thereof | 江苏金浦高新技术研究院有限公司 | 2025-05-30 | — | — | CN | claimed |
| CN-120040940-A | Modified color master batch and preparation method thereof | 惠州市艳丽彩塑胶科技有限公司 | 2025-05-27 | — | — | CN | claimed |
| CN-120025623-A | Linear low-density polyethylene composition for weather-resistant mulching film, and preparation method and application thereof | 中国石油化工股份有限公司 | 2025-05-23 | — | — | CN | claimed |
| CN-120025621-A | Resin composition for cotton packaging film and preparation method and application thereof | 中国石油化工股份有限公司 | 2025-05-23 | — | — | CN | claimed |
| EP-0577816-B1 | POLYSILANE-BASED COMPOSITION | FLAMEL TECH SA (FR) | 1999-04-07 | — | — | EP | claimed |
| EP-0822968-A4 | TRIGGERED ACTIVE PACKAGING MATERIAL | COMMW SCIENT IND RES ORG (AU) | 1998-08-19 | — | — | EP | claimed |
| EP-0822968-A1 | TRIGGERED ACTIVE PACKAGING MATERIAL | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 1998-02-11 | — | — | EP | claimed |
| WO-1996034070-A1 | TRIGGERED ACTIVE PACKAGING MATERIAL | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 1996-10-31 | — | — | WO | claimed |
| EP-0670871-A4 | OXYGEN SCAVENGERS INDEPENDENT OF TRANSITION METAL CATALYSTS. | COMMW SCIENT IND RES ORG (AU) | 1996-02-07 | — | — | EP | claimed |
| EP-0670871-A1 | OXYGEN SCAVENGERS INDEPENDENT OF TRANSITION METAL CATALYSTS | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 1995-09-13 | — | — | EP | claimed |
| WO-1994012590-A1 | OXYGEN SCAVENGERS INDEPENDENT OF TRANSITION METAL CATALYSTS | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 1994-06-09 | — | — | WO | claimed |
| EP-0577816-A1 | POLYSILANE-BASED COMPOSITION | FLAMEL TECHNOLOGIES, Société Anonyme (FR) | 1994-01-12 | — | — | EP | claimed |
| WO-1993014164-A1 | POLYSILANE-BASED COMPOSITION | S.A. FLAMEL TECHNOLOGIES (FR) | 1993-07-22 | — | — | WO | claimed |
| US-5045580-A | Sulfonate type antistatic agent, phosphite or chelating agent stabilizer | POLYPLASTICS CO., LTD. (JP) | 1991-09-03 | — | — | US | claimed |