Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.55 |
| ▸ | WNT3A | P56704 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4409450 | 0.99 | KMT2A (0.59) | TRPA1KMT2ALMNASMN1; SMN2MEN1 | |
| SCHEMBL13570200 | 0.95 | KMT2A (0.60) | TRPA1KMT2ALMNASMN1; SMN2MEN1 | |
| SCHEMBL4416778 | 0.86 | RAB9A (0.63) | TRPA1KMT2ALMNASMN1; SMN2MEN1 | |
| SCHEMBL206581 | 0.81 | ABL1 (0.56) | TRPA1KMT2ALMNASMN1; SMN2MEN1 | |
| SCHEMBL4410618 | 0.80 | MAPT (0.58) | KMT2ALMNASMN1; SMN2MEN1AOC3 | |
| SCHEMBL3941770 | 0.80 | AOC3 (0.68) | KMT2ALMNASMN1; SMN2MEN1AOC3 | |
| SCHEMBL13570326 | 0.80 | LMNA (0.51) | KMT2ALMNASMN1; SMN2MEN1WNT3A | |
| SCHEMBL4420194 | 0.79 | HDAC1 (0.65) | KMT2ALMNASMN1; SMN2MEN1WNT3A | |
| SCHEMBL4408570 | 0.79 | GAA (0.61) | KMT2ALMNASMN1; SMN2MEN1WNT3A | |
| SCHEMBL21586296 | 0.78 | KMT2A (0.74) | KMT2ALMNASMN1; SMN2MEN1WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009144548-A1 | IMIDAZO [2,1-B] PURINE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2009-12-03 | — | — | WO | disclosed |