Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 8/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.38 |
| ▸ | GRM3 | Q14832 | 4/20 | 0.38 |
| ▸ | GRM6 | O15303 | 4/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | GRM8 | O00222 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | PLCB1 | Q9NQ66 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.31 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31178076 | 0.77 | GRM2 (0.31) | GRM4GRM2GRM3GRM6CYP2C19 | |
| SCHEMBL10293983 | 0.75 | GRM4 (0.39) | GRM4GRM2GRM3GRM6CYP2C19 | |
| SCHEMBL4168964 | 0.73 | HSD11B1 (0.36) | ALDH1A1KDM4E | |
| SCHEMBL24583089 | 0.67 | APLNR (0.31) | — | |
| SCHEMBL19819919 | 0.67 | — | — | |
| SCHEMBL152754 | 0.66 | ALDH1A1 (0.40) | GRM4GRM2GRM3GRM6CYP2C19 | |
| SCHEMBL20952430 | 0.65 | ALDH1A1 (0.47) | ALDH1A1KDM4ECYP2C9 | |
| SCHEMBL587339 | 0.64 | FFAR3 (0.35) | GRM4GRM2GRM3GRM6CYP2C19 | |
| SCHEMBL2877125 | 0.64 | GRM2 (0.40) | GRM4GRM2GRM3GRM6CYP2C19 | |
| Hydrochloric Acid SCHEMBL17536887 | 0.64 | PKM (0.39) | GRM4GRM2GRM3GRM6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7635751-B2 | Peptides having ligand activities on APJ that is an orphan G protein-coupled receptor, and use thereof | TAKADA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-12-22 | — | — | US | disclosed |
| EP-1270585-B1 | PEPTIDE DERIVATIVE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2006-05-17 | — | — | EP | disclosed |
| US-20040116336-A1 | Peptide derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-06-17 | — | — | US | disclosed |
| EP-1116727-B1 | PEPTIDE DERIVATIVE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-19 | — | — | EP | disclosed |
| EP-1270585-A1 | PEPTIDE DERIVATIVE | Takeda Chemical Industries, Ltd. (JP) | 2003-01-02 | — | — | EP | disclosed |
| CN-1328568-A | Peptide derivatives | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-12-26 | — | — | CN | disclosed |
| EP-1116727-A1 | PEPTIDE DERIVATIVE | Takeda Chemical Industries, Ltd. (JP) | 2001-07-18 | — | — | EP | disclosed |