Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | CACNA2D1 | P54289 | 6/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.33 |
| ▸ | CACNB1 | Q02641 | 4/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | HTT | P42858 | 3/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.30 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4419615 | 0.86 | OPRD1 (0.39) | OPRD1CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL2796385 | 0.73 | CACNA2D1 (0.53) | OPRD1CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL4426402 | 0.70 | CACNA2D1 (0.51) | OPRD1CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL4563537 | 0.70 | CACNA2D1 (0.43) | OPRD1CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL4565802 | 0.68 | KDM2B (0.36) | HTR7 | |
| SCHEMBL2795860 | 0.67 | CACNA2D1 (0.67) | OPRD1CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL4414806 | 0.67 | KMT2A (0.43) | MEN1KMT2AHTTALDH1A1LMNA | |
| SCHEMBL8210362 | 0.66 | CACNA2D1 (0.48) | OPRD1CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL4427087 | 0.65 | SIGMAR1 (0.35) | CACNA2D1CACNA1BCACNB1CACNA1CCYP2D6 | |
| SCHEMBL8211038 | 0.65 | CACNA2D1 (0.47) | OPRD1CACNA2D1CACNA1BCACNB1CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061780-A1 | DIARYL PIPERIDINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | Neuromed Pharmaceuticals, Ltd. (CA) | 2009-05-27 | — | — | EP | claimed |
| WO-2008031227-A1 | DIARYL PIPERIDINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2008-03-20 | — | — | WO | claimed |