Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 5/20 | 0.44 |
| ▸ | BRAF | P15056 | 10/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | TEK | Q02763 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4410203 | 0.89 | HCAR3 (0.44) | BRAFCYP2C9TEKCHEK1 | |
| SCHEMBL14534461 | 0.88 | CRHR1 (0.47) | CRHR1BRAFCYP2C9MAPK14 | |
| SCHEMBL4411284 | 0.88 | KCNQ3 (0.46) | BRAFCYP2C9TEKMAPK14 | |
| SCHEMBL14534678 | 0.88 | CRHR1 (0.46) | CRHR1BRAFCYP2C9MAPK14 | |
| SCHEMBL5488046 | 0.87 | BRAF (0.44) | BRAFCYP2C9TEK | |
| SCHEMBL4414329 | 0.85 | BRAF (0.43) | BRAFCYP2C9TEK | |
| SCHEMBL4410252 | 0.84 | BRAF (0.46) | BRAFCYP2C9TEK | |
| SCHEMBL14534446 | 0.82 | BRAF (0.43) | BRAFCYP2C9TEK | |
| SCHEMBL4415236 | 0.81 | BRAF (0.41) | BRAFCYP2C9TEK | |
| SCHEMBL4414872 | 0.80 | BRAF (0.49) | BRAFCYP2C9TEKMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |