Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CCKBR | P32239 | 9/20 | 0.39 |
| ▸ | CCKAR | P32238 | 3/20 | 0.39 |
| ▸ | BRD4 | O60885 | 3/20 | 0.37 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.35 |
| ▸ | RBPJ | Q06330 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3180266 | 0.89 | KDM4E (0.43) | KDM4EMEN1ALDH1A1CYP3A4MAPT | |
| SCHEMBL3186755 | 0.85 | OPRK1 (0.40) | MEN1ALDH1A1KMT2ACCKBRCCKAR | |
| SCHEMBL641926 | 0.85 | OPRK1 (0.47) | MEN1ALDH1A1MAPTKMT2ABRD4 | |
| SCHEMBL4703950 | 0.79 | OPRK1 (0.48) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL3183404 | 0.75 | KDM4E (0.37) | KDM4EALDH1A1CCKBRBRD4BRD2 | |
| SCHEMBL6531565 | 0.73 | HPGDS (0.41) | KDM4EALDH1A1 | |
| SCHEMBL7066613 | 0.68 | FGFR1 (0.39) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL11622848 | 0.67 | MEN1 (0.56) | KDM4EMEN1ALDH1A1CYP3A4MAPT | |
| SCHEMBL3968919 | 0.67 | GABRA1 (0.62) | KDM4EMEN1ALDH1A1CYP3A4MAPT | |
| SCHEMBL5802442 | 0.67 | KDM4E (0.43) | KDM4EMEN1ALDH1A1CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318427-A1 | BENZODIAZEPINE DERIVATIVES FOR TREATING HEPATITIS C INFECTION | ARROW THERAPEUTICS LIMITED (GB) | 2009-12-24 | — | — | US | claimed |
| US-20090318427-A1 | BENZODIAZEPINE DERIVATIVES FOR TREATING HEPATITIS C INFECTION | ARROW THERAPEUTICS LIMITED (GB) | 2009-12-24 | — | — | US | disclosed |
| EP-1928465-A1 | BENZODIAZEPINE DERIVATIVES FOR TREATING HEPATITIS C INFECTION | Arrow Therapeutics Limited (GB) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007034127-A1 | BENZODIAZEPINE DERIVATIVES FOR TREATING HEPATITIS C INFECTION | ARROW THERAPEUTICS LIMITED (GB) | 2007-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318427-A1 | BENZODIAZEPINE DERIVATIVES FOR TREATING HEPATITIS C INFECTION | CNR1, GABRA6, SIGMAR1 | FGFR1 4436/4885SRC 3254/4885FGFR2 4532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.