Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.46 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | WNT3A | P56704 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TOP1 | P11387 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28802099 | 0.85 | KDM4E (0.50) | MAPKAPK2TGFBR1MAPK10MAP4K4MAPK14 | |
| SCHEMBL6408354 | 0.85 | MAPK10 (0.55) | MAPKAPK2TGFBR1MAPK10MAP4K4MEN1 | |
| SCHEMBL27562868 | 0.84 | TGFBR1 (0.54) | MAPKAPK2TGFBR1MAPK10MAP4K4TOP1 | |
| SCHEMBL23278789 | 0.82 | TGFBR1 (0.52) | MAPKAPK2TGFBR1MAPK10TOP1MAPT | |
| SCHEMBL13534468 | 0.79 | NOS3 (0.47) | MAPKAPK2TGFBR1SREBF2MEN1KMT2A | |
| SCHEMBL14015421 | 0.76 | SREBF2 (0.50) | SREBF2MAPK10MAP4K4RAB9ANPC1 | |
| SCHEMBL28605297 | 0.76 | MEN1 (0.47) | MAPKAPK2TGFBR1MAPK10MAP4K4MEN1 | |
| SCHEMBL12885515 | 0.76 | KMO (0.48) | MAPKAPK2TGFBR1MAPK10MAP4K4MEN1 | |
| SCHEMBL842265 | 0.76 | CCR1 (0.61) | TGFBR1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL15506226 | 0.75 | TGFBR1 (0.51) | TGFBR1SREBF2MAP4K4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090264446-A9 | Condensed Pyridines as Kinase Inhibitors | PALAU PHARMA, S.A. (ES) | 2009-10-22 | — | — | US | disclosed |
| US-20080318977-A1 | Condensed Pyridines as Kinase Inhibitors | PALAU PHARMA, S.A. (ES) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264446-A9 | Condensed Pyridines as Kinase Inhibitors | MAPK1, MAP4K2, MAP3K1 | MAPKAPK2 21/4885TGFBR1 2486/4885SREBF2 3358/4885 |
| US-20080318977-A1 | Condensed Pyridines as Kinase Inhibitors | MAPK1, MAP4K2, MAP3K1 | MAPKAPK2 21/4885TGFBR1 2486/4885SREBF2 3358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.