⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL440890 | 0.85 | — | — | |
| SCHEMBL440918 | 0.85 | — | — | |
| SCHEMBL10432249 | 0.79 | MMP1 (0.32) | — | |
| SCHEMBL23455660 | 0.78 | TET2 (0.33) | — | |
| SCHEMBL11115709 | 0.69 | — | — | |
| SCHEMBL1819157 | 0.69 | TSHR (0.36) | — | |
| SCHEMBL1155535 | 0.68 | TSHR (0.33) | — | |
| SCHEMBL7166020 | 0.67 | LMNA (0.35) | — | |
| SCHEMBL23455658 | 0.65 | ALDH1A1 (0.32) | — | |
| SCHEMBL2183226 | 0.65 | THRB (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9056880-B2 | Process for producing hydrolysis-resistant silicone compounds | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2015-06-16 | — | — | US | disclosed |
| US-8921449-B2 | Hydrolysis-resistant silicone compounds | JOHNSON & JOHNSON VISION CARE INC. (US) | 2014-12-30 | — | — | US | disclosed |
| US-20140128564-A1 | PROCESS FOR PRODUCING HYDROLYSIS-RESISTANT SILICONE COMPOUNDS | FUJISAWA KAZUHIKO (JP) | 2014-05-08 | — | — | US | disclosed |
| US-8637589-B2 | Silicone prepolymer solutions | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2014-01-28 | — | — | US | disclosed |
| EP-2388281-B1 | SILICONE MONOMER | NOF CORP (JP) | 2013-11-06 | — | — | EP | disclosed |
| US-8481608-B2 | Silicone monomer | NOF CORPORATION (JP) | 2013-07-09 | — | — | US | disclosed |
| US-20130131298-A1 | HYDROLYSIS-RESISTANT SILICONE COMPOUNDS | TORAY INDUSTRIES, INC. (JP) | 2013-05-23 | — | — | US | disclosed |
| US-8399539-B2 | Soluble silicone prepolymers | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2013-03-19 | — | — | US | disclosed |
| US-8288496-B2 | Contact lens and its manufacturing method | NIPPON CONTACT LENS INC. (JP) | 2012-10-16 | — | — | US | disclosed |
| US-20120065348-A1 | SOLUBLE SILICONE PREPOLYMERS | TORAY INDUSTRIES, INC. (JP) | 2012-03-15 | — | — | US | disclosed |
| US-8053539-B2 | Prepared by purifying acrylic siloxanyl containing monomers by distillation in the presence of at least one polymerization inhibitor which can be an alkylhydroquinone or a hydroxynaphthalene; without substantial amounts of polymerization product(s) and without discoloration; contact lenses | JOHNSON & JOHNSON VISION CARE INC. (US) | 2011-11-08 | — | — | US | disclosed |
| US-8040078-B1 | LED dimming circuit | KONINKLIJKE PHILIPS ELECTRONICS N.V. (NL) | 2011-10-18 | — | — | US | disclosed |
| US-20110237701-A1 | CONTACT LENS AND ITS MANUFACTURING METHOD | NIPPON CONTACT LENS INC. (JP) | 2011-09-29 | — | — | US | disclosed |
| EP-2369370-A2 | Contact lens and its manufacturing method | Nippon Contact Lens Inc. (JP) | 2011-09-28 | — | — | EP | disclosed |
| US-20110077322-A1 | Silicone Prepolymer Solutions | TORAY INDUSTRIES, INC. (JP) | 2011-03-31 | — | — | US | disclosed |
| US-7897654-B2 | Silicone prepolymer solutions | JOHNSON & JOHNSON VISION CARE INC. (US) | 2011-03-01 | — | — | US | disclosed |
| US-20110028673-A1 | HYDROLYSIS-RESISTANT SILICONE COMPOUNDS | JOHNSON & JOHNSON VISION CARE, INC. | 2011-02-03 | — | — | US | disclosed |
| US-20090005528-A1 | SOLUBLE SILICONE PREPOLYMERS | JOHNSON & JOHNSON VISION CARE, INC. | 2009-01-01 | — | — | US | disclosed |
| US-20080081850-A1 | Such as reaction of butyldimethylsilanol with 3-trichlorosilylpropyl methacrylate to produce 3-[tris(butyldimethylsiloxy)silyl]propyl methacrylate; steric hindrance, purity; copolymers with acrylate endcapped polysiloxane and acrylic monomers; contact and intraocular lenses, artificial cornea | JOHNSON & JOHNSON VISION CARE, INC. | 2008-04-03 | — | — | US | disclosed |
| US-7317117-B2 | Siloxanyl-containing monomers | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2008-01-08 | — | — | US | disclosed |