SCHEMBL441807

SCHEMBL441807

C=C(C)C(=O)NCCC[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C

nearest known ligand 0.34

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.32
MAPK1 P28482 1/20 0.32
HIF1A Q16665 1/20 0.32
ACHE P22303 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12608735 0.94
SCHEMBL443374 0.86 KDM4E (0.32) KDM4EMAPK1HIF1AACHE
SCHEMBL263454 0.86 KDM4E (0.32) KDM4EMAPK1HIF1AACHE
SCHEMBL514781 0.85 KDM4E (0.31) KDM4EMAPK1HIF1AACHE
SCHEMBL19239962 0.85 KDM4E (0.31) KDM4EMAPK1HIF1AACHE
SCHEMBL170046 0.84 ALDH1A1 (0.39) KDM4EMAPK1HIF1AACHE
SCHEMBL4631077 0.83 KDM4E (0.36) KDM4EMAPK1HIF1AACHE
SCHEMBL12094903 0.82 KDM4E (0.34) KDM4EMAPK1HIF1AACHE
SCHEMBL10754926 0.81 KDM4E (0.35) KDM4EMAPK1HIF1AACHE
SCHEMBL10751335 0.81 KDM4E (0.35) KDM4EMAPK1HIF1AACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 108 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3526277-B1 POLYMERIZABLE POLYDIMETHYLSILOXANE-POLYOXYALKYLENE BLOCK COPOLYMERS ALCON INC (CH) 2020-08-12 EP claimed
EP-3391100-B1 AMPHIPHILIC BRANCHED POLYDIORGANOSILOXANE MACROMERS ALCON INC (CH) 2020-08-12 EP claimed
US-10597479-B2 Amphiphilic branched polydiorganosiloxane macromers ALCON INC. (CH) 2020-03-24 US claimed
US-10465047-B2 Polymerizable polydimethylsiloxane-polyoxyalkylene block copolymers NOVARTIS AG (CH) 2019-11-05 US claimed
EP-3526277-A1 POLYMERIZABLE POLYDIMETHYLSILOXANE-POLYOXYALKYLENE BLOCK COPOLYMERS Novartis AG (CH) 2019-08-21 EP claimed
EP-3526278-A1 CHAIN-EXTENDED POLYDIMETHYLSILOXANE VINYLIC CROSSLINKERS AND USES THEREOF Novartis AG (CH) 2019-08-21 EP claimed
US-10301451-B2 Chain-extended polydimethylsiloxane vinylic crosslinkers and uses thereof NOVARTIS AG (CH) 2019-05-28 US claimed
US-10246543-B2 Hydrophilized polydiorganosiloxane vinylic crosslinkers and uses thereof NOVARTIS AG (CH) 2019-04-02 US claimed
US-20180362697-A1 HYDROPHILIZED POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS AND USES THEREOF ALCON INC. (CH) 2018-12-20 US claimed
EP-3390498-A1 HYDROPHILIZED POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS AND USES THEREOF Novartis AG (CH) 2018-10-24 EP claimed
US-20180100053-A1 CHAIN-EXTENDED POLYDIMETHYLSILOXANE VINYLIC CROSSLINKERS AND USES THEREOF ALCON INC. (CH) 2018-04-12 US claimed
US-20180100038-A1 POLYMERIZABLE POLYDIMETHYLSILOXANE-POLYOXYALKYLENE BLOCK COPOLYMERS ALCON INC. (CH) 2018-04-12 US claimed
WO-2017103790-A1 HYDROPHILIZED POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS AND USES THEREOF NOVARTIS AG (CH) 2017-06-22 WO claimed
WO-2017103792-A1 AMPHIPHILIC BRANCHED POLYDIORGANOSILOXANE MACROMERS NOVARTIS AG (CH) 2017-06-22 WO claimed
US-20170166675-A1 AMPHIPHILIC BRANCHED POLYDIORGANOSILOXANE MACROMERS ALCON INC. (CH) 2017-06-15 US claimed
US-20170166673-A1 HYDROPHILIZED POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS AND USES THEREOF ALCON INC. (CH) 2017-06-15 US claimed
EP-2764065-B1 SACRIFICIAL ADHESIVE COATINGS ROCHAL IND LLC (US) 2017-03-22 EP claimed
EP-2764065-A1 SACRIFICIAL ADHESIVE COATINGS Rochal Industries, LLP (US) 2014-08-13 EP claimed
WO-2013052276-A1 SACRIFICIAL ADHESIVE COATINGS ROCHAL INDUSTRIES, LLP (US) 2013-04-11 WO claimed
US-8263720-B1 Sacrificial adhesive coatings ROCHAL INDUSTRIES, LLP (US) 2012-09-11 US claimed