Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10754926 | 0.95 | KDM4E (0.35) | KDM4EMAPK1HIF1AACHE | |
| SCHEMBL12094903 | 0.93 | KDM4E (0.34) | KDM4EMAPK1HIF1AACHE | |
| SCHEMBL12373211 | 0.90 | KDM4E (0.32) | KDM4EMAPK1HIF1AACHE | |
| SCHEMBL15828189 | 0.88 | KDM4E (0.31) | KDM4EMAPK1HIF1AACHE | |
| SCHEMBL26259471 | 0.88 | KDM4E (0.31) | KDM4EMAPK1HIF1AACHE | |
| SCHEMBL12222638 | 0.88 | KDM4E (0.38) | KDM4EMAPK1HIF1AACHE | |
| SCHEMBL263454 | 0.86 | KDM4E (0.32) | KDM4EMAPK1HIF1AACHE | |
| SCHEMBL441807 | 0.86 | KDM4E (0.32) | KDM4EMAPK1HIF1AACHE | |
| SCHEMBL26688049 | 0.85 | — | — | |
| SCHEMBL514781 | 0.85 | KDM4E (0.31) | KDM4EMAPK1HIF1AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10745518-B2 | Branching-type polyoxyethylene compound and contact lens | NOF CORPORATION (JP) | 2020-08-18 | — | — | US | disclosed |
| US-20190106539-A1 | BRANCHING-TYPE POLYOXYETHYLENE COMPOUND AND CONTACT LENS | NOF CORPORATION (JP) | 2019-04-11 | — | — | US | disclosed |
| US-9056880-B2 | Process for producing hydrolysis-resistant silicone compounds | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2015-06-16 | — | — | US | disclosed |
| US-8921449-B2 | Hydrolysis-resistant silicone compounds | JOHNSON & JOHNSON VISION CARE INC. (US) | 2014-12-30 | — | — | US | disclosed |
| US-20140128564-A1 | PROCESS FOR PRODUCING HYDROLYSIS-RESISTANT SILICONE COMPOUNDS | FUJISAWA KAZUHIKO (JP) | 2014-05-08 | — | — | US | disclosed |
| US-8637589-B2 | Silicone prepolymer solutions | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2014-01-28 | — | — | US | disclosed |
| US-8569538-B2 | Acryloyl materials for molded plastics | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| US-8481608-B2 | Silicone monomer | NOF CORPORATION (JP) | 2013-07-09 | — | — | US | disclosed |
| US-20130131298-A1 | HYDROLYSIS-RESISTANT SILICONE COMPOUNDS | TORAY INDUSTRIES, INC. (JP) | 2013-05-23 | — | — | US | disclosed |
| US-8399539-B2 | Soluble silicone prepolymers | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2013-03-19 | — | — | US | disclosed |
| US-8053539-B2 | Prepared by purifying acrylic siloxanyl containing monomers by distillation in the presence of at least one polymerization inhibitor which can be an alkylhydroquinone or a hydroxynaphthalene; without substantial amounts of polymerization product(s) and without discoloration; contact lenses | JOHNSON & JOHNSON VISION CARE INC. (US) | 2011-11-08 | — | — | US | disclosed |
| US-20110077322-A1 | Silicone Prepolymer Solutions | TORAY INDUSTRIES, INC. (JP) | 2011-03-31 | — | — | US | disclosed |
| US-7897654-B2 | Silicone prepolymer solutions | JOHNSON & JOHNSON VISION CARE INC. (US) | 2011-03-01 | — | — | US | disclosed |
| US-20110028673-A1 | HYDROLYSIS-RESISTANT SILICONE COMPOUNDS | JOHNSON & JOHNSON VISION CARE, INC. | 2011-02-03 | — | — | US | disclosed |
| US-20090171026-A1 | SILICONE PREPOLYMER SOLUTIONS | JOHNSON & JOHNSON VISION CARE, INC. | 2009-07-02 | — | — | US | disclosed |
| US-20090005528-A1 | SOLUBLE SILICONE PREPOLYMERS | JOHNSON & JOHNSON VISION CARE, INC. | 2009-01-01 | — | — | US | disclosed |
| US-20080081850-A1 | Such as reaction of butyldimethylsilanol with 3-trichlorosilylpropyl methacrylate to produce 3-[tris(butyldimethylsiloxy)silyl]propyl methacrylate; steric hindrance, purity; copolymers with acrylate endcapped polysiloxane and acrylic monomers; contact and intraocular lenses, artificial cornea | JOHNSON & JOHNSON VISION CARE, INC. | 2008-04-03 | — | — | US | disclosed |
| US-7317117-B2 | Siloxanyl-containing monomers | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2008-01-08 | — | — | US | disclosed |
| US-20080004401-A1 | SILOXANYL MATERIALS FOR MOLDED PLASTICS | JOHNSON & JOHNSON VISION CARE, INC. | 2008-01-03 | — | — | US | disclosed |
| US-20080004383-A1 | ACRYLOYL MATERIALS FOR MOLDED PLASTICS | TORAY INDUSTRIES, INC. (JP) | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140128564-A1 | PROCESS FOR PRODUCING HYDROLYSIS-RESISTANT SILICONE COMPOUNDS | LSS, PIGS, STS | KDM4E 1904/4885MAPK1 2705/4885HIF1A 4156/4885 |
| US-20090005528-A1 | SOLUBLE SILICONE PREPOLYMERS | NOS3, NOS2, PCNA | KDM4E 3647/4885MAPK1 3212/4885HIF1A 73/4885 |
| US-20080004383-A1 | ACRYLOYL MATERIALS FOR MOLDED PLASTICS | ACR, HAAO, PORCN | KDM4E 1956/4885MAPK1 4110/4885HIF1A 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.