Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 3/20 | 0.42 |
| ▸ | HTR7 | P34969 | 4/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | HTR5A | P47898 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16876680 | 0.87 | ALDH1A1 (0.44) | TSHRALDH1A1KMT2AKDM4EGAA | |
| SCHEMBL18324882 | 0.82 | ALDH1A1 (0.41) | TSHRALDH1A1KMT2AKDM4EGAA | |
| SCHEMBL16876735 | 0.79 | DRD4 (0.52) | TSHRALDH1A1HTR7DRD2DRD1 | |
| SCHEMBL2087680 | 0.79 | TSHR (0.50) | TSHRALDH1A1KDM4EMAPTLRRK2 | |
| SCHEMBL7832606 | 0.75 | LRRK2 (0.40) | TSHRALDH1A1KMT2AKDM4EGAA | |
| SCHEMBL27075570 | 0.75 | IDO1 (0.45) | ALDH1A1KMT2AKDM4EGAAMAPT | |
| SCHEMBL8088583 | 0.73 | TSHR (0.48) | TSHRALDH1A1KMT2AKDM4EMAPT | |
| SCHEMBL27607923 | 0.72 | TSHR (0.50) | TSHRALDH1A1KDM4EGAAMAPT | |
| SCHEMBL9899738 | 0.69 | IDO1 (0.53) | ALDH1A1KDM4EGAAMAPTIDO1 | |
| SCHEMBL6642966 | 0.68 | IDO1 (0.45) | TSHRALDH1A1KMT2AKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2020408-A1 | Pyrrole substituted 2-indolinone protein kinase inhibitors | Sugen, Inc. (US) | 2009-02-04 | — | — | EP | disclosed |
| EP-1453502-A4 | PHARMACEUTICAL FORMULATIONS COMPRISING INDOLINONE DERIVATIVES | SUGEN INC (US) | 2007-01-10 | — | — | EP | disclosed |
| US-7119090-B2 | Pyrrole substituted 2-indolinone protein kinase inhibitors | SUGEN, INC. (US) | 2006-10-10 | — | — | US | disclosed |
| US-7112603-B2 | Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives | AGOURON PHARMACEUTICALS, INC. (US) | 2006-09-26 | — | — | US | disclosed |
| US-7109185-B2 | Pharmaceutical formulations comprising indolinone derivatives | SUGEN, INC. (US) | 2006-09-19 | — | — | US | disclosed |
| EP-1301507-B1 | MANNICH BASE PRODRUGS OF 3 - (PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AND THEIR USE AS MODULATORS OF PROTEIN KINASES | SUGEN INC (US) | 2006-07-19 | — | — | EP | disclosed |
| US-7053113-B2 | Mannich base prodrugs of 3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives | SUGEN, INC. (US) | 2006-05-30 | — | — | US | disclosed |
| CN-1250526-C | Pyrrole substituted 2-indolinone protein kinase inhibitors | SUGEN INC (US) | 2006-04-12 | — | — | CN | disclosed |
| EP-1294711-B8 | 1-(PYRROLIDIN-1-YLMETHYL)-3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AND THEIR USE AS MODULATORS OF PROTEIN KINASES | PHARMACIA & UPJOHN CO LLC (US) | 2006-03-08 | — | — | EP | disclosed |
| US-7008943-B2 | 1-(Pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives | PHARMACIA & UPJOHN COMPANY (US) | 2006-03-07 | — | — | US | disclosed |
| US-20020035140-A1 | 1-(pyrrlolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives | PHARMACIA & UPJOHN COMPANY | 2002-03-21 | — | — | US | disclosed |
| US-20020032204-A1 | Mannich base prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives | SUGEN INCORPORATED | 2002-03-14 | — | — | US | disclosed |
| WO-2001090103-A9 | 3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AND THEIR USE AS PROTEIN KINASE MODULATORS | SUGEN INC (US) | 2002-03-07 | — | — | WO | disclosed |
| WO-2001090104-A2 | -(PYRROLIDIN-1-YLMETHYL)-3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AND THEIR USE AS MODULATORS OF PROTEIN KINASES | PHARMACIA & UPJOHN COMPANY (US) | 2001-11-29 | — | — | WO | disclosed |
| WO-2001090068-A2 | MANNICH BASE PRODRUGS OF 3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AND THEIR USE A MODULATORS OF PROTEIN KINASES | SUGEN, INC. (US) | 2001-11-29 | — | — | WO | disclosed |
| EP-1082305-A4 | PYRROLE SUBSTITUTED 2-INDOLINONE PROTEIN KINASE INHIBITORS | SUGEN INC (US) | 2001-09-26 | — | — | EP | disclosed |
| CN-1311775-A | Pyrrole substituted 2-indolinone protein kinase inhibitors | SUGEN INC (US) | 2001-09-05 | — | — | CN | disclosed |
| WO-2001037820-A2 | IONIZABLE INDOLINONE DERIVATIVES AND THEIR USE AS PTK LIGANDS | SUGEN, INC. (US) | 2001-05-31 | — | — | WO | disclosed |
| EP-1082305-A1 | PYRROLE SUBSTITUTED 2-INDOLINONE PROTEIN KINASE INHIBITORS | Sugen, Inc. (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999061422-A1 | PYRROLE SUBSTITUTED 2-INDOLINONE PROTEIN KINASE INHIBITORS | SUGEN, INC. (US) | 1999-12-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020032204-A1 | Mannich base prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives | DMPK, PNKP, PLK2 | TSHR 3418/4885ALDH1A1 2147/4885KMT2A 2397/4885 |
| US-20020035140-A1 | 1-(pyrrlolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives | PKLR, DMPK, PHKG1 | TSHR 1820/4885ALDH1A1 2726/4885KMT2A 2709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.