Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 3/20 | 0.52 |
| ▸ | DRD2 | P14416 | 3/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4418074 | 0.79 | TSHR (0.50) | DRD2HTR7ALDH1A1DRD1HTR2A | |
| SCHEMBL29325434 | 0.77 | ACHE (0.45) | DRD4DRD2SIGMAR1ACHESMN1; SMN2 | |
| SCHEMBL9389114 | 0.77 | HTR7 (0.69) | DRD4DRD2HTR7DRD3DRD1 | |
| SCHEMBL16876680 | 0.77 | ALDH1A1 (0.44) | DRD2SIGMAR1HTR7SMN1; SMN2ALDH1A1 | |
| SCHEMBL18324882 | 0.75 | ALDH1A1 (0.41) | DRD2HTR7ALDH1A1DRD1HTR2A | |
| SCHEMBL6168606 | 0.74 | OPRL1 (0.52) | DRD4DRD2DRD3ACHE | |
| SCHEMBL2980052 | 0.74 | ACHE (0.47) | DRD4DRD2SIGMAR1DRD3ACHE | |
| SCHEMBL29445321 | 0.74 | OPRL1 (0.52) | DRD4DRD2DRD3ACHE | |
| SCHEMBL15649236 | 0.74 | ACHE (0.47) | DRD4DRD2SIGMAR1DRD3ACHE | |
| SCHEMBL11201755 | 0.73 | DRD4 (0.67) | DRD4DRD2SIGMAR1DRD3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10428049-B2 | TRPA1 modulators | ALGOMEDIX, INC. (US) | 2019-10-01 | — | — | US | disclosed |
| US-20190016701-A1 | TRPA1 MODULATORS | ALGOMEDIX, INC. (US) | 2019-01-17 | — | — | US | disclosed |
| US-9951046-B2 | TRPA1 modulators | ALGOMEDIX, INC. (US) | 2018-04-24 | — | — | US | disclosed |
| US-20170001983-A1 | TRPA1 MODULATORS | ALGOMEDIX, INC. | 2017-01-05 | — | — | US | disclosed |
| EP-3092228-A1 | TRPA1 MODULATORS | Algomedix, Inc. (US) | 2016-11-16 | — | — | EP | disclosed |
| WO-2015103060-A1 | TRPA1 MODULATORS | ALGOMEDIX, INC. (US) | 2015-07-09 | — | — | WO | disclosed |
| WO-2015103060-A1 | TRPA1 MODULATORS | ALGOMEDIX, INC. (US) | 2015-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10428049-B2 | TRPA1 modulators | TRPA1, TRPV1, TRPV2 | DRD4 2266/4885DRD2 1062/4885SIGMAR1 147/4885 |
| US-20170001983-A1 | TRPA1 MODULATORS | TRPA1, TRPV1, TRPV2 | DRD4 2266/4885DRD2 1062/4885SIGMAR1 147/4885 |
| US-20190016701-A1 | TRPA1 MODULATORS | TRPA1, TRPV1, TRPV2 | DRD4 2266/4885DRD2 1062/4885SIGMAR1 147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.