SCHEMBL442001

SCHEMBL442001

CC(C)=CCCC(C)=CCCC(C)=CCBr

nearest known ligand 0.73

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.73
MAPT P10636 2/20 0.64
MEN1 O00255 2/20 0.64
CYP3A4 P08684 2/20 0.64
ALOX15 P16050 2/20 0.64
ALDH1A1 P00352 1/20 0.64
UGT1A1 P22309 1/20 0.64
SQLE Q14534 7/20 0.61
KDM4E B2RXH2 1/20 0.57
FNTA P49354 1/20 0.52
FNTB P49356 1/20 0.52
ICMT O60725 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9238573 1.00 KMT2A (0.73) KMT2AMAPTMEN1CYP3A4ALOX15
SCHEMBL158266 1.00 KMT2A (0.73) KMT2AMAPTMEN1CYP3A4ALOX15
SCHEMBL255003 1.00 KMT2A (0.73) KMT2AMAPTMEN1CYP3A4ALOX15
SCHEMBL16485660 1.00 KMT2A (0.73) KMT2AMAPTMEN1CYP3A4ALOX15
SCHEMBL1586840 1.00 KMT2A (0.73) KMT2AMAPTMEN1CYP3A4ALOX15
SCHEMBL2250076 1.00 KMT2A (0.73) KMT2AMAPTMEN1CYP3A4ALOX15
SCHEMBL158315 1.00 KMT2A (0.73) KMT2AMAPTMEN1CYP3A4ALOX15
SCHEMBL11844736 1.00 KMT2A (0.73) KMT2AMAPTMEN1CYP3A4ALOX15
SCHEMBL11844741 1.00 KMT2A (0.73) KMT2AMAPTMEN1CYP3A4ALOX15
SCHEMBL12293765 1.00 KMT2A (0.73) KMT2AMAPTMEN1CYP3A4ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 414 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12600703-B2 Methods of synthesizing farnesyl dibenzodiazepinones AMO PHARMA LTD. (GB) 2026-04-14 US claimed
US-20230192629-A1 METHODS OF SYNTHESIZING FARNESYL DIBENZODIAZEPINONES AMO PHARMA LTD. (US) 2023-06-22 US claimed
EP-4157283-A1 METHODS OF SYNTHESIZING FARNESYL DIBENZODIAZEPINONES Amo Pharma Ltd. (US) 2023-04-05 EP claimed
CN-115835869-A Process for the synthesis of nifedibenzodiazepinone 阿默制药有限公司 2023-03-21 CN claimed
WO-2021243171-A1 METHODS OF SYNTHESIZING FARNESYL DIBENZODIAZEPINONES AMO PHARMA LTD (US) 2021-12-02 WO claimed
CN-108627647-B Detection and quantification method of post-translational modification proteomics 四川大学 2020-06-19 CN claimed
CN-107417771-A A kind of preparation method of the cysteine polypeptide of farnesyl modification 苏州强耀生物科技有限公司 2017-12-01 CN claimed
WO-2009094534-A1 IMPROVED METHOD FOR PREPARING ISOPRENYL CYSTEINE COMPOUNDS AND ANALOGS THEREOF SIGNUM BIOSCIENCES, INC. (US) 2009-07-30 WO claimed
US-20090192332-A1 Method for Preparing Isoprenyl Cysteine Compounds and Analogs Thereof RAPOLE KESHAVA 2009-07-30 US claimed
CN-1325648-C Improved fermentative carotenoid production HOFFMANN LA ROCHE (NL) 2007-07-11 CN claimed
US-6267945-B1 AADMINSTERING FARNESOL RELATED COMPOUND FOR TREATING CONDITIONS ASSOCIATED WITH N-TYPE CALCIUM CHANNEL ACTIVITY NEUROMED TECHNOLOGIES, INC. (CA) 2001-07-31 US claimed
US-4503240-A Process for preparing 8,12-epoxy-13,14,15,16-tetranorlabdane Consortium F/u/ r Elektrochemische Industrie GmbH (DE) 1985-03-05 US claimed
US-4229356-A Production of vitamin K1 and vitamin K2 WAKUNAGA YAKUHIN KABUSHIKI KAISHA (JP) 1980-10-21 US claimed
JP-55028948-A None JP disclosed
JP-62005996-A None JP disclosed
JP-62005995-A None JP disclosed
US-4028385-A RECTIFICATION KURARAY CO., LTD. (JA) 1977-06-07 US disclosed
US-4001339-A INSECTICIDES HOFFMANN-LA ROCHE INC. (US) 1977-01-04 US disclosed
US-3983177-A FROM UNSATURATED HALIDE AND ESTER RHONE-POULENC S.A. (FR) 1976-09-28 US disclosed
US-3944531-A P-ALKOXY-BENZALDEHYDES, INSECTICIDE HOFFMANN-LA ROCHE INC. (US) 1976-03-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090192332-A1 Method for Preparing Isoprenyl Cysteine Compounds and Analogs Thereof LCAT, LIPA, GPX4 KMT2A 4327/4885MAPT 4815/4885MEN1 4075/4885
US-20230192629-A1 METHODS OF SYNTHESIZING FARNESYL DIBENZODIAZEPINONES FNTB, FNTA, FDPS KMT2A 2803/4885MAPT 2499/4885MEN1 81/4885
US-12600703-B2 Methods of synthesizing farnesyl dibenzodiazepinones NR1H2, NR1H3, NR1H4 KMT2A 2873/4885MAPT 3916/4885MEN1 1587/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.