Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.73 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.64 |
| ▸ | SQLE | Q14534 | 7/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | FNTA | P49354 | 1/20 | 0.52 |
| ▸ | FNTB | P49356 | 1/20 | 0.52 |
| ▸ | ICMT | O60725 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9238573 | 1.00 | KMT2A (0.73) | KMT2AMAPTMEN1CYP3A4ALOX15 | |
| SCHEMBL158266 | 1.00 | KMT2A (0.73) | KMT2AMAPTMEN1CYP3A4ALOX15 | |
| SCHEMBL16485660 | 1.00 | KMT2A (0.73) | KMT2AMAPTMEN1CYP3A4ALOX15 | |
| SCHEMBL1586840 | 1.00 | KMT2A (0.73) | KMT2AMAPTMEN1CYP3A4ALOX15 | |
| SCHEMBL2250076 | 1.00 | KMT2A (0.73) | KMT2AMAPTMEN1CYP3A4ALOX15 | |
| SCHEMBL158315 | 1.00 | KMT2A (0.73) | KMT2AMAPTMEN1CYP3A4ALOX15 | |
| SCHEMBL11844736 | 1.00 | KMT2A (0.73) | KMT2AMAPTMEN1CYP3A4ALOX15 | |
| SCHEMBL11844741 | 1.00 | KMT2A (0.73) | KMT2AMAPTMEN1CYP3A4ALOX15 | |
| SCHEMBL442001 | 1.00 | KMT2A (0.73) | KMT2AMAPTMEN1CYP3A4ALOX15 | |
| SCHEMBL12293765 | 1.00 | KMT2A (0.73) | KMT2AMAPTMEN1CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 189 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240400529-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | STEALTH BIOTHERAPEUTICS INC. (US) | 2024-12-05 | — | — | US | disclosed |
| US-20240368098-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | STEALTH BIOTHERAPEUTICS INC. (US) | 2024-11-07 | — | — | US | disclosed |
| US-20240293339-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF VARIOUS MITOCHONDRIAL DISEASES OR DISORDERS, INCLUDING FRIEDREICH'S ATAXIA | Stealth Bio Therapeutics Inc. (US) | 2024-09-05 | — | — | US | disclosed |
| EP-4034547-B9 | ANTIBIOTIC COMPOUNDS | UNIV LEIDEN (NL) | 2024-09-04 | — | — | EP | disclosed |
| US-12049455-B2 | Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia | STEALTH BIOTHERAPEUTICS INC. (US) | 2024-07-30 | — | — | US | disclosed |
| EP-4393913-A1 | PROCESS FOR THE PREPARATION OF DELTA-TOCOTRIENOL | Peptinovo Biopharma Inc. (US) | 2024-07-03 | — | — | EP | disclosed |
| WO-2024126392-A1 | VECTORIZED NHC IRIDIUM(III) COMPLEXES AND USE THEREOF IN PHOTODYNAMIC THERAPY AND/OR DIAGNOSTIC | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2024-06-20 | — | — | WO | disclosed |
| EP-4385995-A1 | VECTORIZED NHC IRIDIUM(III) COMPLEXES AND USE THEREOF IN PHOTODYNAMIC THERAPY AND/OR DIAGNOSTIC | Centre National de la Recherche Scientifique (FR) | 2024-06-19 | — | — | EP | disclosed |
| EP-4034547-B1 | ANTIBIOTIC COMPOUNDS | UNIV LEIDEN (NL) | 2024-05-22 | — | — | EP | disclosed |
| EP-4351547-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF VARIOUS MITOCHONDRIAL DISEASES OR DISORDERS, INCLUDING FRIEDREICH'S ATAXIA | Stealth BioTherapeutics Inc. (US) | 2024-04-17 | — | — | EP | disclosed |
| EP-0356866-A2 | Phosphorus-containing squalene synthetase inhibitors and method | E.R. SQUIBB & SONS, INC. (US) | 1990-03-07 | — | — | EP | disclosed |
| US-4871721-A | HYPOCHOLESTEROLEMIC AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1989-10-03 | — | — | US | disclosed |
| EP-0324421-A2 | Phosporus-containing squalene synthetase inhibitors, new intermediates and method | E.R. Squibb & Sons, Inc. (US) | 1989-07-19 | — | — | EP | disclosed |
| US-4709079-A | ANTI-INFLAMMATORY AGENT | EISAI CO., LTD. (JP) | 1987-11-24 | — | — | US | disclosed |
| US-4595783-A | Magnesium chloride or phosphonium halide derivatives of 3,7,11-trimethyl-dodeca-2,6(10)-diene(triene)-1-ol | VOGEL FRIEDRICH (US) | 1986-06-17 | — | — | US | disclosed |
| US-4576963-A | ANTIINFLAMMATORY, ANTIARTHRITIC, ANTIRHEUMATIC | EISAI CO., LTD. (JP) | 1986-03-18 | — | — | US | disclosed |
| US-4544758-A | Vitamin E intermediates and methods for the preparation of (2R,4'RS,8'RS)-α-tocopherol and (all-rac)-α-tocopherol via the new intermediate products | BASF AKTIENGESELLSCHAFT (DE) | 1985-10-01 | — | — | US | disclosed |
| US-4455316-A | Polyprenyl esters of acemethacins and anti-inflammatory method of use thereof | EISAI CO., LTD. (JP) | 1984-06-19 | — | — | US | disclosed |
| US-4001339-A | INSECTICIDES | HOFFMANN-LA ROCHE INC. (US) | 1977-01-04 | — | — | US | disclosed |
| US-3944531-A | P-ALKOXY-BENZALDEHYDES, INSECTICIDE | HOFFMANN-LA ROCHE INC. (US) | 1976-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240293339-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF VARIOUS MITOCHONDRIAL DISEASES OR DISORDERS, INCLUDING FRIEDREICH'S ATAXIA | AIFM2, FH, FECH | KMT2A 3296/4885MAPT 322/4885MEN1 2003/4885 |
| US-20240400529-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | FH, COQ8A, TFAM | KMT2A 2420/4885MAPT 1057/4885MEN1 4392/4885 |
| US-12049455-B2 | Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia | FH, COQ8A, TFAM | KMT2A 2420/4885MAPT 1057/4885MEN1 4392/4885 |
| US-20240368098-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | FH, COQ8A, TFAM | KMT2A 2420/4885MAPT 1057/4885MEN1 4392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.