Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 2/20 | 0.49 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 6/20 | 0.42 |
| ▸ | JAK1 | P23458 | 5/20 | 0.42 |
| ▸ | CDK2 | P24941 | 8/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 6/20 | 0.42 |
| ▸ | CDK9 | P50750 | 6/20 | 0.42 |
| ▸ | CDK1 | P06493 | 6/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.42 |
| ▸ | CCND3 | P30281 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 2/20 | 0.41 |
| ▸ | CCNH | P51946 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4427810 | 0.81 | EGFR (0.45) | SYKEGFR | |
| SCHEMBL4410317 | 0.81 | TAAR1 (0.48) | JAK3CDK2CDK9CDK5CCNA2 | |
| SCHEMBL4414428 | 0.81 | EGFR (0.47) | TNNI3KEGFRERBB2MAPK1SLC2A1 | |
| SCHEMBL4412798 | 0.80 | ROCK1 (0.50) | ROCK1AURKAEGFRNEK2 | |
| SCHEMBL4416584 | 0.77 | MEN1 (0.41) | CDK2CCNT1CDK9CCNE1CA2 | |
| SCHEMBL350165 | 0.76 | TNNI3K (0.38) | ROCK1TNNI3KJAK3JAK1CDK2 | |
| SCHEMBL4417806 | 0.76 | SYK (0.43) | ROCK1SYKROCK2MAP4K4EGFR | |
| SCHEMBL4414478 | 0.75 | PLAU (0.39) | ROCK1SYKMAP4K4EGFRMAPK8 | |
| SCHEMBL4421897 | 0.74 | MAPK1 (0.39) | EGFRMAPK1 | |
| SCHEMBL351895 | 0.74 | IRAK4 (0.43) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601713-B2 | Kinase inhibitors and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2009-10-13 | — | — | US | claimed |