Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | TDO2 | P48775 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 2/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4417948 | 0.89 | GAA (0.43) | MAPK1PIK3CAKDM4EMEN1GAA | |
| SCHEMBL4410317 | 0.83 | TAAR1 (0.48) | MAPK1KDM4EMEN1KMT2AHSD17B10 | |
| SCHEMBL4428827 | 0.79 | EGFR (0.50) | MAPTEGFR | |
| SCHEMBL4427810 | 0.78 | EGFR (0.45) | PIK3CAMEN1GFERKMT2AMAPT | |
| SCHEMBL4414428 | 0.78 | EGFR (0.47) | MAPK1GFERHSD17B10EGFRHTT | |
| SCHEMBL4414311 | 0.78 | EGFR (0.53) | MEN1KMT2AMAPTEGFR | |
| SCHEMBL4411564 | 0.78 | CDC7 (0.49) | MAPK1KDM4EMEN1GAAKMT2A | |
| SCHEMBL4413885 | 0.78 | FYN (0.46) | KDM4EMEN1GAAKMT2AHSD17B10 | |
| SCHEMBL4412315 | 0.75 | ABCG2 (0.44) | MEN1KMT2AMAPTEGFRSMN1; SMN2 | |
| SCHEMBL4412798 | 0.75 | ROCK1 (0.50) | EGFRHDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601713-B2 | Kinase inhibitors and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2009-10-13 | — | — | US | claimed |