Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | BCR | P11274 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | NEK2 | P51955 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4427810 | 0.84 | EGFR (0.45) | EGFR | |
| SCHEMBL4414428 | 0.81 | EGFR (0.47) | ABL1EGFR | |
| SCHEMBL4410317 | 0.81 | TAAR1 (0.48) | ABL1EGFR | |
| SCHEMBL4420185 | 0.80 | ROCK1 (0.49) | ROCK1NEK2AURKAEGFR | |
| SCHEMBL4414478 | 0.78 | PLAU (0.39) | ROCK1EGFR | |
| SCHEMBL4417806 | 0.77 | SYK (0.43) | ROCK1EGFR | |
| SCHEMBL1306083 | 0.76 | IRAK4 (0.49) | — | |
| SCHEMBL4421897 | 0.75 | MAPK1 (0.39) | EGFRHDAC11 | |
| SCHEMBL4417948 | 0.72 | GAA (0.43) | ROCK1AURKA | |
| SCHEMBL4428827 | 0.72 | EGFR (0.50) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601713-B2 | Kinase inhibitors and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2009-10-13 | — | — | US | claimed |