Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18048654 | 0.95 | KMT2A (0.63) | MEN1KMT2AHPGDHDAC6HDAC1 | |
| SCHEMBL11720766 | 0.87 | KMT2A (0.68) | MEN1KMT2AHPGDNPC1RAB9A | |
| SCHEMBL28801149 | 0.84 | POLB (0.65) | MEN1KMT2AHPGDHDAC6HDAC1 | |
| SCHEMBL15480417 | 0.84 | HDAC1 (0.73) | MEN1KMT2AHDAC6HDAC1HDAC2 | |
| SCHEMBL4654699 | 0.84 | MEN1 (0.63) | MEN1KMT2AHPGDHDAC6HDAC1 | |
| SCHEMBL28573978 | 0.83 | L3MBTL1 (0.56) | MEN1KMT2AHDAC6HDAC1HDAC2 | |
| SCHEMBL28412042 | 0.83 | MEN1 (0.54) | MEN1KMT2AHDAC6HDAC1HDAC2 | |
| SCHEMBL22479429 | 0.83 | MEN1 (0.61) | MEN1KMT2AHPGDHDAC6HDAC1 | |
| SCHEMBL30034675 | 0.83 | HDAC1 (0.73) | MEN1KMT2AHPGDHDAC6HDAC1 | |
| SCHEMBL16178940 | 0.83 | HDAC1 (0.52) | MEN1KMT2AHDAC6HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8541572-B2 | Compounds for the treatment of inflammatory disorders | MERCK SHARP & DOHME CORP. (US) | 2013-09-24 | — | — | US | disclosed |
| US-8541572-B2 | Compounds for the treatment of inflammatory disorders | MERCK SHARP & DOHME CORP. (US) | 2013-09-24 | — | — | US | disclosed |
| US-20120010181-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | MERCK SHARP & DOHME CORP. | 2012-01-12 | — | — | US | disclosed |
| US-20120010181-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | MERCK SHARP & DOHME CORP. | 2012-01-12 | — | — | US | disclosed |
| US-7517517-B2 | Radiolabelled quinoline and quinolinone derivatives and their use as metabotropic glutamate receptor ligands | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-14 | — | — | US | disclosed |
| US-20060083676-A1 | Radiolabelled quinoline and quinolinone derivatives and their use as metabotropic glutamate receptor ligands | JANSSEN PHARMACEUTIA N.V. (BE) | 2006-04-20 | — | — | US | disclosed |
| EP-1492571-A2 | RADIOLABELLED QUINOLINE AND QUINOLINONE DERIVATIVES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR LIGANDS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003082350-A2 | RADIOLABELLED QUINOLINE AND QUINOLINONE DERIVATIVES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR LIGANDS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-10-09 | — | — | WO | disclosed |
| CN-1100057-C | New chromene compounds, process for their preparation and pharmaceutical compositions containing them | SEUVERE LAB (FR) | 2003-01-29 | — | — | CN | disclosed |
| US-6365605-B1 | ADMINISTERING D.SUB.3 RECEPTOR LIGAND FOR THERAPY OF CONDITIONS SELECTED FROM DEPRESSION, SCHIZOPHRENIA, PSYCHOSES, PARKINSONS'S DISEASE, MEMORY DISORDERS, AND DISORDERS ASSOCIATED WITH DRUG ABUSE | LES LABORATOIRES SERVIER (FR) | 2002-04-02 | — | — | US | disclosed |
| US-6326377-B1 | PSYCHOLOGICAL DISORDERS THERAPY | ADIR ET COMPAGNIE (FR) | 2001-12-04 | — | — | US | disclosed |
| EP-0887350-B1 | Chromene derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-08-22 | — | — | EP | disclosed |
| US-6090837-A | PSYCHOLOGICAL DISORDERS | ADIR ET COMPAGNIE (FR) | 2000-07-18 | — | — | US | disclosed |
| EP-0887350-A1 | Chromene derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1998-12-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010181-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | TNF, ADAMTS1, ADAMTS7 | MEN1 1882/4885KMT2A 4446/4885HPGD 249/4885 |
| US-20060083676-A1 | Radiolabelled quinoline and quinolinone derivatives and their use as metabotropic glutamate receptor ligands | GRM3, GRM1, GRM2 | MEN1 2520/4885KMT2A 2490/4885HPGD 1640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.