Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | GLA | P06280 | 2/20 | 0.49 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.46 |
| ▸ | EPRS1 | P07814 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | PPARG | P37231 | 3/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.43 |
| ▸ | DHODH | Q02127 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20495103 | 0.84 | HTT (0.53) | TSHRHTTKDM4EGLARXFP1 | |
| SCHEMBL16621492 | 0.83 | HAVCR2 (0.47) | TSHRKDM4EHAVCR2KMT2AALDH1A1 | |
| SCHEMBL741418 | 0.83 | HTT (0.55) | TSHRHTTKDM4EGLAEPRS1 | |
| SCHEMBL10281891 | 0.82 | HTT (0.49) | TSHRHTTKDM4ERXFP1ALDH1A1 | |
| SCHEMBL10282067 | 0.81 | TSHR (0.45) | TSHRHTTKDM4ERXFP1KMT2A | |
| SCHEMBL440033 | 0.81 | KEAP1 (0.49) | HAVCR2RXFP1MEN1KMT2AALDH1A1 | |
| SCHEMBL436603 | 0.81 | KDM4E (0.48) | TSHRKDM4EHAVCR2MEN1KMT2A | |
| SCHEMBL440411 | 0.81 | HAVCR2 (0.52) | TSHRHAVCR2MEN1KMT2AALDH1A1 | |
| SCHEMBL7490398 | 0.81 | HTT (0.50) | TSHRHTTKDM4EGLARXFP1 | |
| SCHEMBL439271 | 0.79 | MAPK1 (0.65) | TSHRHTTKDM4ERXFP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3140303-B1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2018-03-28 | — | — | EP | disclosed |
| US-20120065166-A1 | Bone Modulators And Methods Therewith | ESPINA VIRGINIA (US) | 2012-03-15 | — | — | US | disclosed |