SCHEMBL4422677

SCHEMBL4422677

C=CCc1c(Br)c(Br)cc2c1[nH]c1ccccc12

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHR P35869 2/20 0.38
MAPT P10636 2/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
ALDH1A1 P00352 3/20 0.36
HSD17B10 Q99714 2/20 0.36
GPR3 P46089 1/20 0.36
LMNA P02545 2/20 0.36
MAPK1 P28482 2/20 0.36
HTT P42858 2/20 0.36
KDM4E B2RXH2 2/20 0.36
KIF11 P52732 4/20 0.35
IDO1 P14902 2/20 0.34
GABRP O00591 1/20 0.34
GABRD O14764 1/20 0.34
GABRA1 P14867 1/20 0.34
GABRB1 P18505 1/20 0.34
GABRG2 P18507 1/20 0.34
GABRB3 P28472 1/20 0.34
GABRA5 P31644 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2641042 0.78 AHR (0.47) AHRMAPTMEN1KMT2AALDH1A1
SCHEMBL28761242 0.76 ALDH1A1 (0.48) AHRMAPTMEN1KMT2AALDH1A1
SCHEMBL6576224 0.75 MAPK1 (0.46) MAPTMEN1KMT2AALDH1A1HSD17B10
SCHEMBL6678688 0.74 HSD17B10 (0.49) MEN1KMT2AALDH1A1HSD17B10KDM4E
SCHEMBL27830682 0.74 MAPK1 (0.44) MAPTMEN1KMT2AALDH1A1HSD17B10
SCHEMBL10453934 0.74 KIF11 (0.44) MAPTALDH1A1HSD17B10GPR3LMNA
SCHEMBL15845424 0.71 KIF11 (0.55) AHRMAPTMEN1KMT2AALDH1A1
SCHEMBL31474797 0.71 KIF11 (0.55) AHRMAPTMEN1KMT2AALDH1A1
SCHEMBL2641043 0.71 MAPT (0.42) AHRMAPTMEN1KMT2AALDH1A1
SCHEMBL28198631 0.70 CHRNA7 (0.52) KMT2AALDH1A1HSD17B10PIM1PIM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1923385-B1 Iridium complex, carbazole derivatives and copolymer having the same KWANGJU INST SCI & TECH (KR) 2009-05-27 EP claimed
US-20080177084-A1 IRIDIUM COMPLEX, CARBAZOLE DERIVATIVES AND COPOLYMER HAVING THE SAME GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2008-07-24 US claimed
EP-1923385-A1 Iridium complex, carbazole derivatives and copolymer having the same Gwangju Institute of Science and Technology (KR) 2008-05-21 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080177084-A1 IRIDIUM COMPLEX, CARBAZOLE DERIVATIVES AND COPOLYMER HAVING THE SAME INTS9, HIRIP3, HELZ AHR 377/4885MAPT 1247/4885MEN1 3437/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.