Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4411964 | 0.91 | TTBK1 (0.49) | MAPTMAPK1HTTTBK1NPC1 | |
| SCHEMBL4423422 | 0.78 | AXL (0.50) | — | |
| SCHEMBL351023 | 0.74 | ADORA3 (0.45) | MAPTGAAMAPK1HTTXBP1 | |
| SCHEMBL350535 | 0.73 | SYK (0.41) | MAPTGAAMAPK1HTTXBP1 | |
| SCHEMBL4422876 | 0.73 | PIK3CG (0.38) | HTTSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL4412660 | 0.73 | ALDH1A1 (0.37) | MAPTMAPK1HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4413885 | 0.72 | FYN (0.46) | MAPTGAASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL4428827 | 0.71 | EGFR (0.50) | MAPTNPC1RAB9AEGFRSYK | |
| SCHEMBL4414428 | 0.70 | EGFR (0.47) | MAPK1HTTSMN1; SMN2RAB9ANPSR1 | |
| SCHEMBL4427810 | 0.70 | EGFR (0.45) | MAPTHTTMEN1KMT2ATTBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601713-B2 | Kinase inhibitors and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2009-10-13 | — | — | US | claimed |