Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18252689 | 0.84 | GAA (0.42) | NPSR1MEN1KMT2AGAACA12 | |
| SCHEMBL17289001 | 0.83 | GAA (0.44) | MEN1KMT2AGAACA12CA1 | |
| SCHEMBL29449955 | 0.83 | AOX1 (0.43) | NPSR1MEN1KMT2AGAACA12 | |
| SCHEMBL15871416 | 0.80 | NPSR1 (0.48) | NPSR1MEN1KMT2ACA12CA1 | |
| SCHEMBL12230058 | 0.79 | ALDH1A1 (0.40) | GAACA12CA1CA2CA9 | |
| SCHEMBL13636979 | 0.79 | NPSR1 (0.47) | NPSR1MEN1KMT2ACA12CA1 | |
| SCHEMBL2364152 | 0.79 | MEN1 (0.54) | NPSR1MEN1KMT2AGAACA12 | |
| SCHEMBL916035 | 0.79 | NPSR1 (0.47) | NPSR1MEN1KMT2ACA12CA1 | |
| SCHEMBL7187605 | 0.79 | NPSR1 (0.47) | NPSR1MEN1KMT2ACA12CA1 | |
| SCHEMBL2034316 | 0.79 | NPSR1 (0.47) | NPSR1MEN1KMT2ACA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8044091-B2 | Phospho-indoles as HIV inhibitors | IDENIX PHARMACEUTICALS, INC. (US) | 2011-10-25 | — | — | US | disclosed |
| US-8044091-B2 | Phospho-indoles as HIV inhibitors | IDENIX PHARMACEUTICALS, INC. (US) | 2011-10-25 | — | — | US | disclosed |
| EP-2256124-A1 | Phospho-indoles as HIV inhibitors | IDENIX Pharmaceuticals, Inc. (US) | 2010-12-01 | — | — | EP | disclosed |
| EP-1961757-B1 | Phosphoindoles as HIV inhibitors | IDENIX PHARMACEUTICALS INC (US) | 2010-09-01 | — | — | EP | disclosed |
| US-20090292135-A1 | ORGANOMETAL BENZENEPHOSPHONATE COUPLING AGENTS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2009-11-26 | — | — | US | disclosed |
| US-20090292135-A1 | ORGANOMETAL BENZENEPHOSPHONATE COUPLING AGENTS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2009-11-26 | — | — | US | disclosed |
| US-20090292135-A1 | ORGANOMETAL BENZENEPHOSPHONATE COUPLING AGENTS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2009-11-26 | — | — | US | disclosed |
| US-20090163444-A1 | PHOSPHO-INDOLES AS HIV INHIBITORS | IDENIX PHARMACEUTICALS LLC | 2009-06-25 | — | — | US | disclosed |
| US-20090163444-A1 | PHOSPHO-INDOLES AS HIV INHIBITORS | IDENIX PHARMACEUTICALS LLC | 2009-06-25 | — | — | US | disclosed |
| US-7534809-B2 | Phospho-indoles as HIV inhibitors | IDENIX PHARMACEUTICALS, INC. (US) | 2009-05-19 | — | — | US | disclosed |
| EP-1799696-B1 | PHOSPHOINDOLES AS HIV INHIBITORS | IDENIX PHARMACEUTICALS INC (US) | 2008-11-12 | — | — | EP | disclosed |
| EP-1961757-A1 | Phosphoindoles as HIV inhibitors | IDENIX Pharmaceuticals, Inc. (US) | 2008-08-27 | — | — | EP | disclosed |
| CN-101212978-A | Organometal benzenephosphonate coupling agents | MICROBIA INC (US) | 2008-07-02 | — | — | CN | disclosed |
| EP-1885378-A2 | ORGANOMETAL BENZENEPHOSPHONATE COUPLING AGENTS | Microbia, Inc. (US) | 2008-02-13 | — | — | EP | disclosed |
| EP-1517895-B1 | 8-(BIARYL) QUINOLINE PDE4 INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2007-03-14 | — | — | EP | disclosed |
| US-7153968-B2 | 8-(biaryl)quinoline PDE4 inhibitors | MERCK FROSST CANADA, LTD. (CA) | 2006-12-26 | — | — | US | disclosed |
| WO-2006122117-A2 | ORGANOMETAL BENZENEPHOSPHONATE COUPLING AGENTS | MICROBIA, INC. (US) | 2006-11-16 | — | — | WO | disclosed |
| US-20050234238-A1 | 8-(Biaryl)quinoline pde4 inhibitors | MERCK FROSST CANADA LTD. (CA) | 2005-10-20 | — | — | US | disclosed |
| EP-1517895-A1 | 8-(BIARYL) QUINOLINE PDE4 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 2005-03-30 | — | — | EP | disclosed |
| WO-2004000814-A1 | 8-(BIARYL) QUINOLINE PDE4 INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2003-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163444-A1 | PHOSPHO-INDOLES AS HIV INHIBITORS | IDO1, PPP5C, INMT | NPSR1 2490/4885MEN1 3483/4885KMT2A 1767/4885 |
| US-20050234238-A1 | 8-(Biaryl)quinoline pde4 inhibitors | IL4, PDE4A, PDE4C | NPSR1 1758/4885MEN1 4605/4885KMT2A 4486/4885 |
| US-20090292135-A1 | ORGANOMETAL BENZENEPHOSPHONATE COUPLING AGENTS | ZNF207, TST, BOLA2; BOLA2B | NPSR1 2790/4885MEN1 1650/4885KMT2A 2095/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.