Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.46 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 4/20 | 0.39 |
| ▸ | JAK3 | P52333 | 4/20 | 0.39 |
| ▸ | JAK1 | P23458 | 3/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | GNRHR | P30968 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2722945 | 0.99 | MAPT (0.56) | MAPTALDH1A1PKML3MBTL1LMNA | |
| SCHEMBL15163843 | 0.81 | MAPT (0.61) | MAPTALDH1A1PKML3MBTL1LMNA | |
| SCHEMBL17166117 | 0.79 | ALDH1A1 (0.67) | MAPTALDH1A1PKML3MBTL1LMNA | |
| SCHEMBL21523663 | 0.78 | ALDH1A1 (0.66) | MAPTALDH1A1PKML3MBTL1LMNA | |
| SCHEMBL4430476 | 0.78 | POLB (0.44) | MAPTALDH1A1LMNASTIM1ORAI1 | |
| SCHEMBL4425839 | 0.74 | STIM1 (0.65) | MAPTALDH1A1STIM1ORAI1KLKB1 | |
| SCHEMBL2720956 | 0.74 | STIM1 (0.50) | STIM1ORAI1KLKB1CA5AJAK2 | |
| SCHEMBL15520765 | 0.73 | ALDH1A1 (1.00) | MAPTALDH1A1PKML3MBTL1LMNA | |
| SCHEMBL18393799 | 0.72 | MAPT (0.40) | MAPTALDH1A1PKML3MBTL1LMNA | |
| SCHEMBL21523604 | 0.72 | MAPT (0.55) | MAPTALDH1A1PKML3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9156791-B2 | Pyrazole compounds acting against allergic, immune and inflammatory conditions | GLAXO GROUP LIMITED (GB) | 2015-10-13 | — | — | US | disclosed |
| US-9156791-B2 | Pyrazole compounds acting against allergic, immune and inflammatory conditions | GLAXO GROUP LIMITED (GB) | 2015-10-13 | — | — | US | disclosed |
| US-9149462-B2 | Pyrazole compounds acting against allergic, inflammatory and immune disorders | GLAXO GROUP LIMITED (GB) | 2015-10-06 | — | — | US | disclosed |
| US-9149462-B2 | Pyrazole compounds acting against allergic, inflammatory and immune disorders | GLAXO GROUP LIMITED (GB) | 2015-10-06 | — | — | US | disclosed |
| EP-2630126-B1 | PYRAZOLE COMPOUNDS ACTING AGAINST ALLERGIC, IMMUNE AND INFLAMMATORY CONDITIONS | GLAXO GROUP LTD (GB) | 2015-01-07 | — | — | EP | disclosed |
| US-20130217658-A1 | PYRAZOLE COMPOUNDS ACTING AGAINST ALLERGIC, INFLAMMATORY AND IMMUNE DISORDERS | GLAXO GROUP LIMITED (GB) | 2013-08-22 | — | — | US | disclosed |
| US-20130217658-A1 | PYRAZOLE COMPOUNDS ACTING AGAINST ALLERGIC, INFLAMMATORY AND IMMUNE DISORDERS | GLAXO GROUP LIMITED (GB) | 2013-08-22 | — | — | US | disclosed |
| US-20130203705-A1 | Pyrazole Compounds Acting Against Allergic, Immune and Inflammatory Conditions | GLAXO GROUP LIMITED (GB) | 2013-08-08 | — | — | US | disclosed |
| US-20130203705-A1 | Pyrazole Compounds Acting Against Allergic, Immune and Inflammatory Conditions | GLAXO GROUP LIMITED (GB) | 2013-08-08 | — | — | US | disclosed |
| WO-2012052459-A1 | PYRAZOLE COMPOUNDS ACTING AGAINST ALLERGIC, INFLAMMATORY AND IMMUNE DISORDERS | GLAXO GROUP LIMITED (GB) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012052458-A1 | PYRAZOLE COMPOUNDS ACTING AGAINST ALLERGIC, IMMUNE AND INFLAMMATORY CONDITIONS | GLAXO GROUP LIMITED (GB) | 2012-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130203705-A1 | Pyrazole Compounds Acting Against Allergic, Immune and Inflammatory Conditions | NLRP3, IL33, IL5 | MAPT 979/4885ALDH1A1 991/4885PKM 1119/4885 |
| US-20130217658-A1 | PYRAZOLE COMPOUNDS ACTING AGAINST ALLERGIC, INFLAMMATORY AND IMMUNE DISORDERS | NLRP3, IL33, IL5 | MAPT 1522/4885ALDH1A1 814/4885PKM 1191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.