Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | HTR3A | P46098 | 5/20 | 0.58 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.53 |
| ▸ | TNF | P01375 | 1/20 | 0.51 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.51 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.51 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.51 |
| ▸ | GALR3 | O60755 | 1/20 | 0.51 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 6/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4435849 | 0.93 | HTR3A (0.67) | KDM4EHTR3AHRH1CYP2D6KCNH2 | |
| SCHEMBL20715423 | 0.84 | CYP2D6 (0.66) | NPSR1MEN1MAPTKMT2AKDM4E | |
| SCHEMBL20715427 | 0.83 | CYP2D6 (0.64) | NPSR1MEN1MAPTKMT2AKDM4E | |
| SCHEMBL7168715 | 0.82 | HTR3A (0.81) | KDM4EHTR3ATNFHRH1CYP2D6 | |
| SCHEMBL15963052 | 0.79 | NPSR1 (0.61) | NPSR1MEN1MAPTKMT2AKDM4E | |
| SCHEMBL7667116 | 0.79 | — | — | |
| SCHEMBL8879490 | 0.79 | HTR3A (0.71) | NPSR1MEN1MAPTKMT2AKDM4E | |
| SCHEMBL10967129 | 0.76 | HTR3A (0.71) | HTR3A | |
| SCHEMBL9513301 | 0.76 | DRD2 (0.56) | MEN1KMT2AGAAMAPK1HRH1 | |
| SCHEMBL4428154 | 0.76 | HSD11B1 (0.58) | MEN1MAPTKMT2AKDM4EHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090239880-A1 | COMBINATIONS OF MONOAMINE REUPTAKE INHIBITORS AND POTASSIUM CHANNEL ACTIVATORS | NEUROSEARCH A/S (DK) | 2009-09-24 | — | — | US | disclosed |
| EP-2043641-A2 | COMBINATIONS OF MONOAMINE REUPTAKE INHIBITORS AND POTASSIUM CHANNEL ACTIVATORS | NeuroSearch A/S (DK) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008003667-A2 | COMBINATIONS OF MONOAMINE REUPTAKE INHIBITORS AND POTASSIUM CHANNEL ACTIVATORS | NEUROSEARCH A/S (DK) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239880-A1 | COMBINATIONS OF MONOAMINE REUPTAKE INHIBITORS AND POTASSIUM CHANNEL ACTIVATORS | SLC6A2, SLC18A2, SLC6A4 | NPSR1 180/4885MEN1 2754/4885MAPT 1098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.