Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | BRS3 | P32247 | 6/20 | 0.37 |
| ▸ | KDM6B | O15054 | 3/20 | 0.36 |
| ▸ | KDM4A | O75164 | 3/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.36 |
| ▸ | HIF1AN | Q9NWT6 | 3/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.36 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | KDM3B | Q7LBC6 | 2/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 1/20 | 0.35 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.35 |
| ▸ | BAD | Q92934 | 1/20 | 0.35 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.34 |
| ▸ | BCL2 | P10415 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4432204 | 0.90 | KDM4E (0.43) | KDM4EBRS3KDM6BKDM4AKDM4D | |
| SCHEMBL4433040 | 0.85 | MDM2 (0.41) | KDM4EMAPTMAPK1SMN1; SMN2PKM | |
| SCHEMBL4438825 | 0.83 | BRS3 (0.42) | KDM4EBRS3MAPTSMN1; SMN2 | |
| SCHEMBL4433888 | 0.82 | KDM4E (0.53) | KDM4EBRS3KDM6BKDM4AKDM4D | |
| SCHEMBL4438823 | 0.81 | KDM4E (0.44) | KDM4EBRS3KDM6BKDM4AKDM4D | |
| SCHEMBL4430684 | 0.81 | RXRA (0.41) | KDM4EBRS3PTGER4MCL1 | |
| SCHEMBL4430746 | 0.78 | CYP1A2 (0.48) | KDM4EBRS3MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL4430819 | 0.77 | BRS3 (0.46) | KDM4EBRS3 | |
| SCHEMBL4432530 | 0.76 | KDM4E (0.47) | KDM4EKDM6BKDM4AKDM4DHIF1AN | |
| SCHEMBL4428820 | 0.76 | KDM4E (0.47) | KDM4EKDM6BKDM4AKDM4DHIF1AN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |