Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4425949 | 0.84 | NOTUM (0.42) | ALDH1A1KDM4EMAPTMDM2CA1 | |
| SCHEMBL4428256 | 0.77 | MDM2 (0.44) | PDE3BPDE3AALDH1A1KDM4EPOLB | |
| SCHEMBL4428822 | 0.76 | RXRA (0.47) | PDE3BPDE3AALDH1A1KDM4EPOLB | |
| SCHEMBL4432962 | 0.76 | MDM2 (0.42) | PDE3BPDE3AALDH1A1KDM4EPOLB | |
| SCHEMBL4431889 | 0.75 | ALDH1A1 (0.49) | PDE3BPDE3AALDH1A1KDM4EPOLB | |
| SCHEMBL4429517 | 0.75 | TSHR (0.46) | PDE3BPDE3AALDH1A1KDM4EPOLB | |
| SCHEMBL10004025 | 0.74 | ALDH1A1 (0.57) | ALDH1A1KDM4EPOLBMAPTLMNA | |
| SCHEMBL4432534 | 0.73 | KDM4E (0.49) | PDE3BPDE3AALDH1A1KDM4EMAPT | |
| SCHEMBL4433040 | 0.73 | MDM2 (0.41) | PDE3BPDE3AALDH1A1KDM4EPOLB | |
| SCHEMBL4438837 | 0.72 | ALDH1A1 (0.49) | PDE3BPDE3AALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |