SCHEMBL44283

SCHEMBL44283

[c]1cccn1-c1ccccc1

nearest known ligand 0.32

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.31
KDM4E B2RXH2 2/20 0.31
ATM Q13315 2/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
MGLL Q99685 1/20 0.31
HPGD P15428 1/20 0.31
DDB1 Q16531 1/20 0.30
CRBN Q96SW2 1/20 0.30
GAA P10253 2/20 0.30
GSK3A P49840 2/20 0.30
GSK3B P49841 2/20 0.30
SIGMAR1 Q99720 1/20 0.30
MEN1 O00255 1/20 0.30
NPC1 O15118 1/20 0.30
RAB9A P51151 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11574910 0.74 MGLL (0.44) CYP3A4SMN1; SMN2MGLLSIGMAR1MEN1
SCHEMBL300545 0.74 KEAP1 (0.43) L3MBTL1MGLLGAAMEN1KMT2A
SCHEMBL6441670 0.72
SCHEMBL535999 0.69 MGLL (0.39) SMN1; SMN2KDM4EMGLLMEN1RAB9A
SCHEMBL1377544 0.65 KDM4E (0.35) CYP3A4KDM4EATML3MBTL1MGLL
SCHEMBL17023766 0.63 RPS6KA5 (0.32) KDM4E
SCHEMBL63013 0.63 CYP3A4 (0.40) CYP3A4SMN1; SMN2KDM4EATML3MBTL1
SCHEMBL4800641 0.62 CYP3A4 (0.39) CYP3A4KDM4EHPGDGAAMEN1
SCHEMBL10946472 0.61 ATM (0.44) SMN1; SMN2KDM4EATMMGLLHPGD
SCHEMBL1573901 0.58 ALDH1A1 (0.50) KDM4EATML3MBTL1MGLLHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 5770 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118206575-A Boron-containing organic compound and organic electroluminescent device prepared from same 华为技术有限公司 2024-06-18 CN claimed
CN-118043308-A Bond formation method based on coupling reaction 中外制药株式会社 2024-05-14 CN claimed
US-11952460-B2 Polycarbonate resin, method for producing the same, and optical lens MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2024-04-09 US claimed
EP-3901147-B1 ACYLAMINO BRIDGED HETEROCYCLIC COMPOUND, AND COMPOSITION AND APPLICATION THEREOF BEIJING SCITECH MQ PHARMACEUTICALS LTD (CN) 2023-11-22 EP claimed
CN-115960345-A Polycarbonate resin, method for producing same, and optical lens 三菱瓦斯化学株式会社 2023-04-14 CN claimed
WO-2023054715-A1 METHOD FOR FORMING BOND THROUGH COUPLING REACTION 中外製薬株式会社 2023-04-06 WO claimed
US-20230026425-A1 ACYLAMINO BRIDGED HETEROCYCLIC COMPOUND, AND COMPOSITION AND APPLICATION THEREOF BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED (CN) 2023-01-26 US claimed
CN-113166116-B Amido bridged heterocyclic compound, and composition and application thereof 北京赛特明强医药科技有限公司 2022-12-27 CN claimed
CN-114752053-A Polycarbonate resin, method for producing same, and optical lens 三菱瓦斯化学株式会社 2022-07-15 CN claimed
CN-114716658-A Polycarbonate resin, method for producing same, and optical lens 三菱瓦斯化学株式会社 2022-07-08 CN claimed
US-6358978-B1 FOR THERAPY AND PROPHYLAXIS OF RHEUMATOID ARTHRITIS (IN THE CASE OF INFLAMMATION), OSTEOARTHRITIS, ASTHMA, CARDIAC INFARCT, ALZHEIMER'S DISEASE, OR ATHEROSCLEROSIS AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2002-03-19 US claimed
EP-1042291-A1 ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS Klinge Pharma GmbH (DE) 2000-10-11 EP claimed
WO-1999031064-A1 ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS KLINGE PHARMA GMBH (DE) 1999-06-24 WO claimed
EP-0299972-B1 ANTHELMINTIC QUATERNARYALKYL ACYLHYDRAZONES, METHOD OF USE AND COMPOSITIONS THE UPJOHN COMPANY (US) 1992-03-04 EP claimed
EP-0201221-B1 6-(1-ACYL-1-HYDROXY METHYL) PENICILLANIC ACID DERIVATIVES PFIZER INC. (US) 1990-08-01 EP claimed
EP-0299972-A1 ANTHELMINTIC QUATERNARYALKYL ACYLHYDRAZONES, METHOD OF USE AND COMPOSITIONS. UPJOHN CO (US) 1989-01-25 EP claimed
US-4762921-A 6-(1-acyl-1-hydroxymethyl)penicillanic acid derivatives PFIZER INC. (US) 1988-08-09 US claimed
WO-1987006132-A1 ANTHELMINTIC QUATERNARYALKYL ACYLHYDRAZONES, METHOD OF USE AND COMPOSITIONS THE UPJOHN COMPANY (US) 1987-10-22 WO claimed
US-4675186-A 6-(1-acyl-1-hydroxymethyl)penicillanic acid derivatives PFIZER INC. (US) 1987-06-23 US claimed
EP-0201221-A1 6-(1-acyl-1-hydroxy methyl) penicillanic acid derivatives PFIZER INC. (US) 1986-11-12 EP claimed