Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 7/20 | 0.47 |
| ▸ | RXRB | P28702 | 2/20 | 0.47 |
| ▸ | RXRG | P48443 | 2/20 | 0.47 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.46 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | RARA | P10276 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | RARB | P10826 | 1/20 | 0.43 |
| ▸ | RARG | P13631 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4431033 | 0.85 | RXRA (0.59) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL4431889 | 0.79 | ALDH1A1 (0.49) | ALDH1A1L3MBTL1MAPTLMNAPDE3B | |
| SCHEMBL4429488 | 0.76 | PDE3B (0.47) | ALDH1A1L3MBTL1MAPTLMNAPDE3B | |
| SCHEMBL4429517 | 0.76 | TSHR (0.46) | ALDH1A1L3MBTL1MAPTLMNAPDE3B | |
| SCHEMBL10004025 | 0.73 | ALDH1A1 (0.57) | ALDH1A1L3MBTL1MAPTLMNAGAA | |
| SCHEMBL4987734 | 0.72 | MAPT (0.44) | RXRARXRBRXRGALDH1A1RARA | |
| SCHEMBL3819796 | 0.71 | RARB (0.60) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL10458353 | 0.71 | TSHR (0.53) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL8674523 | 0.70 | RARA (0.56) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL21776893 | 0.70 | PPARG (0.59) | RXRARXRBRXRGCYP26A1CYP26B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |