Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 13/20 | 0.59 |
| ▸ | RXRB | P28702 | 7/20 | 0.59 |
| ▸ | RXRG | P48443 | 6/20 | 0.59 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.53 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.53 |
| ▸ | RARA | P10276 | 6/20 | 0.46 |
| ▸ | RARB | P10826 | 6/20 | 0.46 |
| ▸ | RARG | P13631 | 6/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4428822 | 0.85 | RXRA (0.47) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL4428237 | 0.77 | KDM4E (0.50) | — | |
| SCHEMBL3912930 | 0.76 | KDM4E (0.53) | — | |
| SCHEMBL4432424 | 0.76 | HNF4A (0.49) | — | |
| SCHEMBL10459825 | 0.75 | RXRA (0.63) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL11835232 | 0.75 | KDM4E (0.59) | — | |
| SCHEMBL4431596 | 0.75 | KDM4E (0.45) | — | |
| SCHEMBL4372824 | 0.75 | KDM5A (0.55) | RXRARXRBRXRG | |
| SCHEMBL11836193 | 0.74 | KDM4E (0.42) | — | |
| SCHEMBL4380912 | 0.74 | HCAR2 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |