SCHEMBL443060

SCHEMBL443060

COc1ccc(-n2c(-c3ccccc3)c3ccccc3c2-c2ccccc2)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.57
MAPT P10636 2/20 0.57
ALDH1A1 P00352 5/20 0.55
OXTR P30559 1/20 0.53
GLA P06280 1/20 0.51
NPSR1 Q6W5P4 2/20 0.51
RAB9A P51151 1/20 0.51
G6PD P11413 1/20 0.50
MEN1 O00255 4/20 0.48
KMT2A Q03164 4/20 0.48
CYP1A2 P05177 1/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2D6 P10635 1/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
SIRT1 Q96EB6 1/20 0.48
ATM Q13315 1/20 0.48
HTT P42858 1/20 0.47
ACACA Q13085 1/20 0.46
HPGD P15428 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL445315 0.87 OXTR (0.51) LMNAMAPTALDH1A1OXTRGLA
SCHEMBL443120 0.83 SMN1; SMN2 (0.56) MAPTALDH1A1KMT2ACYP1A2CYP3A4
SCHEMBL443174 0.81 MAPT (0.60) LMNAMAPTALDH1A1NPSR1RAB9A
SCHEMBL1077703 0.81 MAPT (0.49) LMNAMAPTALDH1A1OXTRGLA
SCHEMBL443170 0.80 KDM4E (0.52) LMNAMAPTALDH1A1MEN1KMT2A
SCHEMBL445355 0.79 ALDH1A1 (0.48) ALDH1A1NPSR1RAB9ACYP2D6CYP2C9
SCHEMBL12387069 0.77 ALDH1A1 (0.53) LMNAMAPTALDH1A1OXTRGLA
SCHEMBL2146511 0.76 MAPT (0.54) LMNAMAPTALDH1A1NPSR1RAB9A
SCHEMBL29539968 0.76 MAPT (0.62) LMNAMAPTALDH1A1OXTRG6PD
SCHEMBL29415 0.76 MAPT (0.62) LMNAMAPTALDH1A1OXTRG6PD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8809543-B2 Electrophotographic photoreceptor, electrophotographic image forming method, electrophotographic image forming apparatus, and process cartridge for electrophotographic image forming apparatus RICOH COMPANY, LTD. (JP) 2014-08-19 US disclosed
US-8809543-B2 Electrophotographic photoreceptor, electrophotographic image forming method, electrophotographic image forming apparatus, and process cartridge for electrophotographic image forming apparatus RICOH COMPANY, LTD. (JP) 2014-08-19 US disclosed
US-20120064443-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC IMAGE FORMING METHOD, ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE FOR ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2012-03-15 US disclosed
US-20120064443-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC IMAGE FORMING METHOD, ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE FOR ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2012-03-15 US disclosed