SCHEMBL445355

SCHEMBL445355

Cc1ccc(-n2c(-c3ccccc3)c3ccccc3c2-c2ccccc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.48
SMN1; SMN2 Q16637 4/20 0.47
KDM4E B2RXH2 3/20 0.47
MAPK1 P28482 1/20 0.47
HPGD P15428 1/20 0.47
PPARG P37231 1/20 0.47
NCOA2 Q15596 1/20 0.47
NCOA1 Q15788 1/20 0.47
HTT P42858 2/20 0.45
CYP2C9 P11712 2/20 0.45
NPSR1 Q6W5P4 2/20 0.44
RAB9A P51151 2/20 0.44
METAP2 P50579 1/20 0.42
TDP1 Q9NUW8 1/20 0.41
NPC1 O15118 1/20 0.41
RXFP1 Q9HBX9 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C19 P33261 1/20 0.40
IL1R1 P14778 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL443170 0.85 KDM4E (0.52) ALDH1A1SMN1; SMN2KDM4EMAPK1HPGD
SCHEMBL5012008 0.84 ALDH1A1 (0.47) ALDH1A1SMN1; SMN2KDM4EMAPK1HPGD
SCHEMBL5012020 0.82 ALDH1A1 (0.46) ALDH1A1SMN1; SMN2KDM4EMAPK1HPGD
SCHEMBL442621 0.81 ALDH1A1 (0.40) ALDH1A1KDM4EHPGDCYP2C9NPSR1
SCHEMBL443111 0.79 GAA (0.51) ALDH1A1SMN1; SMN2MAPK1HPGDRAB9A
SCHEMBL445312 0.79 TP53 (0.45) ALDH1A1SMN1; SMN2KDM4EHTTRAB9A
SCHEMBL5014207 0.79 SMN1; SMN2 (0.47) ALDH1A1SMN1; SMN2KDM4EMAPK1HPGD
SCHEMBL443060 0.79 LMNA (0.57) ALDH1A1SMN1; SMN2KDM4EHPGDHTT
SCHEMBL23665412 0.78 ALDH1A1 (0.46) ALDH1A1SMN1; SMN2KDM4EMAPK1HPGD
SCHEMBL16552366 0.78 IL1R1 (0.47) ALDH1A1SMN1; SMN2KDM4EMAPK1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8809543-B2 Electrophotographic photoreceptor, electrophotographic image forming method, electrophotographic image forming apparatus, and process cartridge for electrophotographic image forming apparatus RICOH COMPANY, LTD. (JP) 2014-08-19 US disclosed
US-8809543-B2 Electrophotographic photoreceptor, electrophotographic image forming method, electrophotographic image forming apparatus, and process cartridge for electrophotographic image forming apparatus RICOH COMPANY, LTD. (JP) 2014-08-19 US disclosed
US-20120064443-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC IMAGE FORMING METHOD, ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE FOR ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2012-03-15 US disclosed
US-20120064443-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC IMAGE FORMING METHOD, ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE FOR ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2012-03-15 US disclosed