SCHEMBL443120

SCHEMBL443120

COc1cccc(-n2c(-c3ccccc3)c3ccccc3c2-c2ccccc2)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.56
USP2 O75604 2/20 0.50
ABCG2 Q9UNQ0 1/20 0.50
CYP1A2 P05177 3/20 0.49
CYP3A4 P08684 3/20 0.49
CYP2C9 P11712 3/20 0.49
CYP2B6 P20813 2/20 0.49
AHR P35869 2/20 0.49
NR1I3 Q14994 2/20 0.49
VDR P11473 1/20 0.49
ADORA2A P29274 1/20 0.48
TSHR P16473 2/20 0.47
ALDH1A1 P00352 2/20 0.47
KDM4E B2RXH2 1/20 0.47
MAPT P10636 1/20 0.47
MAPK1 P28482 2/20 0.46
HSD17B10 Q99714 2/20 0.46
CYP2D6 P10635 2/20 0.46
F2 P00734 1/20 0.46
HPGD P15428 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL445320 0.89 SMN1; SMN2 (0.52) SMN1; SMN2USP2ABCG2CYP1A2CYP3A4
SCHEMBL443060 0.83 LMNA (0.57) SMN1; SMN2CYP1A2CYP3A4CYP2C9ALDH1A1
SCHEMBL444779 0.83 SMN1; SMN2 (0.49) SMN1; SMN2USP2CYP3A4ALDH1A1KDM4E
SCHEMBL443111 0.79 GAA (0.51) SMN1; SMN2ADORA2ATSHRALDH1A1MAPT
SCHEMBL443170 0.78 KDM4E (0.52) SMN1; SMN2CYP1A2CYP2C9TSHRALDH1A1
SCHEMBL14454763 0.77 KDM4E (0.55) SMN1; SMN2USP2CYP1A2ALDH1A1KDM4E
SCHEMBL532536 0.76 TSPO (0.47) SMN1; SMN2ALDH1A1KDM4EMAPTHSD17B10
SCHEMBL27864514 0.76 TSPO (0.53) SMN1; SMN2USP2ALDH1A1KDM4EMAPT
SCHEMBL31070137 0.76 ABCG2 (0.48) SMN1; SMN2ABCG2TSHRKMT2A
SCHEMBL443171 0.75 MGLL (0.45) SMN1; SMN2ALDH1A1MAPTKMT2AALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8809543-B2 Electrophotographic photoreceptor, electrophotographic image forming method, electrophotographic image forming apparatus, and process cartridge for electrophotographic image forming apparatus RICOH COMPANY, LTD. (JP) 2014-08-19 US disclosed
US-8809543-B2 Electrophotographic photoreceptor, electrophotographic image forming method, electrophotographic image forming apparatus, and process cartridge for electrophotographic image forming apparatus RICOH COMPANY, LTD. (JP) 2014-08-19 US disclosed
US-20120064443-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC IMAGE FORMING METHOD, ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE FOR ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2012-03-15 US disclosed
US-20120064443-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC IMAGE FORMING METHOD, ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE FOR ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2012-03-15 US disclosed