Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | BRS3 | P32247 | 5/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.36 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4438825 | 0.88 | BRS3 (0.42) | KDM4EBRS3CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL4433888 | 0.85 | KDM4E (0.53) | KDM4EBRS3 | |
| SCHEMBL4430746 | 0.83 | CYP1A2 (0.48) | KDM4EBRS3PTGER3CYP1A2CYP2D6 | |
| SCHEMBL4429595 | 0.81 | KDM4E (0.40) | KDM4EBRS3PTGER4MCL1 | |
| SCHEMBL4425949 | 0.80 | NOTUM (0.42) | RXRARXRBRXRGKDM4ENOTUM | |
| SCHEMBL4432204 | 0.78 | KDM4E (0.43) | KDM4EBRS3PTGER4CYP2C9TSHR | |
| SCHEMBL4430819 | 0.77 | BRS3 (0.46) | KDM4EBRS3 | |
| SCHEMBL4438823 | 0.76 | KDM4E (0.44) | KDM4EBRS3 | |
| SCHEMBL4438513 | 0.75 | KDM4E (0.47) | KDM4ECYP1A2CYP2D6CYP2C9TSHR | |
| SCHEMBL4432962 | 0.74 | MDM2 (0.42) | KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |