Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4437699 | 0.91 | SLC6A3 (0.55) | KDM4EGLAGAAALDH1A1MAPT | |
| SCHEMBL4431012 | 0.87 | SLC6A3 (0.58) | KDM4EGLAGAAALDH1A1MAPT | |
| SCHEMBL4433888 | 0.85 | KDM4E (0.53) | KDM4EGAAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL4426834 | 0.85 | ALDH1A1 (0.54) | KDM4EGLAGAAALDH1A1MAPT | |
| SCHEMBL4439655 | 0.84 | MAPK8 (0.45) | KDM4EGLAGAAALDH1A1MAPT | |
| SCHEMBL4431808 | 0.83 | KDM4E (0.50) | KDM4EGLAGAAALDH1A1MAPT | |
| SCHEMBL4426842 | 0.82 | KDM4E (0.49) | KDM4EGLAGAAALDH1A1MAPT | |
| SCHEMBL5154097 | 0.81 | KDM4E (0.54) | KDM4EGLAGAAALDH1A1MAPT | |
| SCHEMBL4438532 | 0.79 | ALDH1A1 (0.47) | KDM4EGLAGAAALDH1A1MAPT | |
| SCHEMBL4432962 | 0.78 | MDM2 (0.42) | KDM4EGAAALDH1A1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |