Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | HNF4A | P41235 | 1/20 | 0.37 |
| ▸ | RARA | P10276 | 1/20 | 0.36 |
| ▸ | BRS3 | P32247 | 4/20 | 0.35 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.35 |
| ▸ | KDM6B | O15054 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.34 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4429595 | 0.81 | KDM4E (0.40) | KDM4EBRS3KDM6BKDM4AKDM4D | |
| SCHEMBL4432204 | 0.80 | KDM4E (0.43) | KDM4EBRS3KDM6BKDM4AKDM4D | |
| SCHEMBL4433888 | 0.77 | KDM4E (0.53) | KDM4EHNF4ABRS3KDM6BKDM4A | |
| SCHEMBL4438825 | 0.77 | BRS3 (0.42) | KDM4EBRS3SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL4430684 | 0.76 | RXRA (0.41) | KDM4EBRS3 | |
| SCHEMBL4433258 | 0.72 | KDM4E (0.55) | KDM4EHNF4ABRS3KDM6BKDM4A | |
| SCHEMBL4430692 | 0.71 | KDM4E (0.51) | KDM4EHNF4AKDM6BKDM4AKDM4D | |
| SCHEMBL4425949 | 0.71 | NOTUM (0.42) | KDM4EBRS3KDM6BKDM4AKDM4D | |
| SCHEMBL3912930 | 0.71 | KDM4E (0.53) | KDM4EHNF4ABRS3KDM6BKDM4A | |
| SCHEMBL4430819 | 0.70 | BRS3 (0.46) | KDM4EBRS3FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |