Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4219487 | 0.86 | MAPT (0.53) | ALDH1A1KDM4EHPGDHSD17B10AKR1C2 | |
| SCHEMBL4233003 | 0.85 | MAPT (0.50) | ALDH1A1KDM4EHPGDHSD17B10AKR1C2 | |
| SCHEMBL5070134 | 0.81 | KDM4E (0.49) | ALDH1A1KDM4EHPGDHSD17B10AKR1C2 | |
| SCHEMBL852717 | 0.79 | AKR1C2 (0.76) | ALDH1A1KDM4EHPGDHSD17B10AKR1C2 | |
| SCHEMBL4225100 | 0.77 | MAPT (0.40) | ALDH1A1KDM4EHPGDMAPTPPARG | |
| SCHEMBL29484404 | 0.75 | MAPT (0.51) | ALDH1A1KDM4EHPGDHSD17B10AKR1C2 | |
| SCHEMBL4223932 | 0.75 | MAPT (0.41) | ALDH1A1KDM4EHPGDMAPTPPARG | |
| SCHEMBL9127829 | 0.71 | KDM4E (0.86) | ALDH1A1KDM4EHPGDHSD17B10AKR1C2 | |
| SCHEMBL4542962 | 0.71 | POLB (0.45) | ALDH1A1MAPTMEN1KMT2APOLB | |
| SCHEMBL4543849 | 0.71 | RAPGEF4 (0.37) | ALDH1A1KDM4EMAPTEGFRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648867-A4 | PPAR ACTIVE COMPOUNDS | PLEXXIKON INC (US) | 2008-07-23 | — | — | EP | claimed |
| JP-2007534625-A | — | — | 2007-11-29 | — | — | JP | claimed |
| EP-1648867-A1 | PPAR ACTIVE COMPOUNDS | PLEXXIKON, INC. (US) | 2006-04-26 | — | — | EP | claimed |
| WO-2005009958-A1 | PPAR ACTIVE COMPOUNDS | PLEXXIKON, INC. (US) | 2005-02-03 | — | — | WO | claimed |
| EP-2121591-A2 | PPAR ACTIVE COMPOUNDS | PLEXXIKON, INC. (US) | 2009-11-25 | — | — | EP | disclosed |
| EP-2114879-A1 | PPAR ACTIVE COMPOUNDS | PLEXXIKON, INC. (US) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008109700-A1 | PPAR ACTIVE COMPOUNDS | PLEXXIKON, INC. (US) | 2008-09-12 | — | — | WO | disclosed |
| WO-2008109697-A2 | PPAR ACTIVE COMPOUNDS | PLEXXIKON, INC. (US) | 2008-09-12 | — | — | WO | disclosed |
| EP-1648867-A4 | PPAR ACTIVE COMPOUNDS | PLEXXIKON INC (US) | 2008-07-23 | — | — | EP | disclosed |
| EP-1943245-A2 | 1,3-DISUBSTITUTED INDOLE DERIVATIVES FOR USE AS PPAR MODULATORS | PLEXXIKON, INC. (US) | 2008-07-16 | — | — | EP | disclosed |
| EP-1940767-A2 | PPARACTIVE COMPOUNDS | PLEXXIKON, INC. (US) | 2008-07-09 | — | — | EP | disclosed |
| EP-1931658-A2 | 1 , 4 AND 1 , 5-DISUBSTITUTED INDOLE DERIVATIVES FOR USE AS PPAR ACTIVE COMPOUNDS | PLEXXIKON, INC. (US) | 2008-06-18 | — | — | EP | disclosed |
| EP-1819673-A2 | INDOLE DERIVATIVES FOR USE AS PPAR ACTIVE COMPOUNDS | PLEXXIKON, INC. (US) | 2007-08-22 | — | — | EP | disclosed |
| WO-2007030559-A2 | 1, 3-DISUBSTITUTED INDOLE DERIVATIVES FOR USE AS PPAR MODULATORS | PLEXXIKON, INC. (US) | 2007-03-15 | — | — | WO | disclosed |
| WO-2007030574-A2 | 1 , 4 AND 1 , 5-DISUBSTITUTED INDOLE DERIVATIVES FOR USE AS PPAR ACTIVE COMPOUNDS | PLEXXIKON, INC. (US) | 2007-03-15 | — | — | WO | disclosed |
| WO-2007030567-A2 | PPARACTIVE COMPOUNDS | PLEXXIKON, INC. (US) | 2007-03-15 | — | — | WO | disclosed |
| WO-2006060535-A2 | INDOLE DERIVATIVES FOR USE AS PPAR ACTIVE COMPOUNDS | PLEXXIKON, INC. (US) | 2006-06-08 | — | — | WO | disclosed |
| WO-2006060456-A2 | INDOLE DERIVATIVES FOR USE AS PPAR PPAR ACTIVE COMPOUNDS | PLEXXIKON, INC. (US) | 2006-06-08 | — | — | WO | disclosed |
| EP-1648867-A1 | PPAR ACTIVE COMPOUNDS | PLEXXIKON, INC. (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005009958-A1 | PPAR ACTIVE COMPOUNDS | PLEXXIKON, INC. (US) | 2005-02-03 | — | — | WO | disclosed |