Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 3/20 | 0.45 |
| ▸ | HTR6 | P50406 | 3/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | HTR5A | P47898 | 2/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | HTR1E | P28566 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4223932 | 0.89 | MAPT (0.41) | MAPTALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL4430853 | 0.86 | ALDH1A1 (0.60) | MAPTALDH1A1KDM4EHPGDHTR1D | |
| SCHEMBL4233003 | 0.86 | MAPT (0.50) | MAPTALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL4543849 | 0.85 | RAPGEF4 (0.37) | MAPTALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL4224408 | 0.84 | POLB (0.48) | MAPTHPGDNPC1LMNARAB9A | |
| SCHEMBL4219372 | 0.84 | LMNA (0.41) | MAPTHPGDLMNAMEN1GAA | |
| SCHEMBL4225055 | 0.84 | SMN1; SMN2 (0.44) | MAPTALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL4225100 | 0.77 | MAPT (0.40) | MAPTALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL4233057 | 0.77 | GPR17 (0.38) | MAPTSMN1; SMN2LMNAMEN1GAA | |
| SCHEMBL4223918 | 0.77 | POLB (0.43) | MAPTSMN1; SMN2NPC1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009006089-A2 | A2 ADENOSINE RECEPTOR AGONISTS | GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2009-01-08 | — | — | WO | disclosed |