Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | HTR1D | P28221 | 2/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | HTR1E | P28566 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR5A | P47898 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4225100 | 0.92 | MAPT (0.40) | MAPTALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL4542962 | 0.86 | POLB (0.45) | MAPTHTR6ALDH1A1HTR1AHTR7 | |
| SCHEMBL4219487 | 0.86 | MAPT (0.53) | MAPTHTR1DHTR6ALDH1A1KDM4E | |
| SCHEMBL4430853 | 0.85 | ALDH1A1 (0.60) | MAPTHTR1DHTR6ALDH1A1KDM4E | |
| SCHEMBL4231056 | 0.83 | EGFR (0.46) | HTR6ALDH1A1SMN1; SMN2GFER | |
| SCHEMBL4543731 | 0.80 | POLB (0.40) | — | |
| SCHEMBL4540052 | 0.80 | GPR17 (0.37) | MAPTHTR6SMN1; SMN2LMNAMEN1 | |
| SCHEMBL4223932 | 0.80 | MAPT (0.41) | MAPTALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL18317950 | 0.74 | CA12 (0.43) | MAPTALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL4223972 | 0.73 | GPR17 (0.37) | MAPTHTR6ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009006089-A2 | A2 ADENOSINE RECEPTOR AGONISTS | GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2009-01-08 | — | — | WO | disclosed |