Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 3/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4233003 | 0.92 | MAPT (0.50) | MAPTMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL4223932 | 0.88 | MAPT (0.41) | MAPTMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL4542962 | 0.86 | POLB (0.45) | MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL4231056 | 0.83 | EGFR (0.46) | SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL4540052 | 0.80 | GPR17 (0.37) | MAPTMEN1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL4543731 | 0.80 | POLB (0.40) | — | |
| SCHEMBL4219487 | 0.77 | MAPT (0.53) | MAPTMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL4430853 | 0.77 | ALDH1A1 (0.60) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL4223972 | 0.73 | GPR17 (0.37) | MAPTKMT2AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL4543849 | 0.71 | RAPGEF4 (0.37) | MAPTMEN1KMT2AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009006089-A2 | A2 ADENOSINE RECEPTOR AGONISTS | GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2009-01-08 | — | — | WO | disclosed |