Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.40 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4428708 | 0.82 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A1SLC6A11ALDH1A1 | |
| SCHEMBL3693305 | 0.78 | SLC6A11 (0.49) | SLC6A3SLC6A2SLC6A4SLC6A1SLC6A11 | |
| SCHEMBL17928455 | 0.73 | KIF11 (0.46) | SLC6A1SLC6A11ALDH1A1HSD17B10KMT2A | |
| SCHEMBL14405387 | 0.71 | CHRNB4 (0.51) | SLC6A1SLC6A11 | |
| SCHEMBL26502805 | 0.71 | CHRNB4 (0.51) | SLC6A1SLC6A11 | |
| SCHEMBL8341127 | 0.70 | SLC6A11 (0.44) | SLC6A3SLC6A2SLC6A4SLC6A1SLC6A11 | |
| SCHEMBL15019554 | 0.67 | SLC6A3 (0.40) | SLC6A3SLC6A2SLC6A4HPGDCYP2D6 | |
| SCHEMBL4424977 | 0.67 | KIF11 (0.43) | SLC6A2SLC6A4ALDH1A1MAPK1MEN1 | |
| SCHEMBL715992 | 0.67 | KIF11 (0.50) | KIF11 | |
| SCHEMBL20833231 | 0.66 | SLC6A2 (0.58) | SLC6A3SLC6A2SLC6A4ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081949-A2 | TRIPARTITE OLIGONUCLEOTIDE COMPLEXES AND METHODS FOR GENE SILENCING BY RNA INTERFERENCE | Dharmacon, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| EP-2064223-A2 | DUPLEX OLIGONUCLEOTIDE COMPLEXES AND METHODS FOR GENE SILENCING BY RNA INTERFERENCE | Dharmacon, Inc. (US) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008036825-A2 | DUPLEX OLIGONUCLEOTIDE COMPLEXES AND METHODS FOR GENE SILENCING BY RNA INTERFERENCE | DHARMACON, INC. (US) | 2008-03-27 | — | — | WO | disclosed |
| WO-2008036841-A2 | TRIPARTITE OLIGONUCLEOTIDE COMPLEXES AND METHODS FOR GENE SILENCING BY RNA INTERFERENCE | DHARMACON, INC. (US) | 2008-03-27 | — | — | WO | disclosed |